Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Neostigmine
Drug ID BADD_D01553
Description A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
Indications and Usage Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
Marketing Status Prescription
ATC Code N07AA01; S01EB06
DrugBank ID DB01400
KEGG ID D08261
MeSH ID D009388
PubChem ID 4456
TTD Drug ID D08USJ
NDC Product Code 43598-529; 71872-7178; 43598-528
Synonyms Neostigmine | Synstigmin | Proserine | Prozerin | Polstigmine | Neostigmine Bromide | Bromide, Neostigmine | Syntostigmine | Neostigmine Methylsulfate | Methylsulfate, Neostigmine | Prostigmine | Prostigmin
Chemical Information
Molecular Formula C12H19N2O2+
CAS Registry Number 59-99-4
SMILES CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agitation19.06.02.001; 17.02.05.012--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Coma17.02.09.001--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Insomnia17.15.03.002; 19.02.01.002--
Lacrimation increased06.08.02.004--
Laryngeal pain22.02.05.036--
The 1th Page    1 2 3    Next   Last    Total 3 Pages