Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nalbuphine hydrochloride
Drug ID BADD_D01520
Description A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Indications and Usage For the relief of moderate to severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AF02
DrugBank ID DB00844
KEGG ID D00843
MeSH ID D009266
PubChem ID 5360733
TTD Drug ID D06ZXH
NDC Product Code 0409-1463; 50396-0201; 0409-1465; 52584-464; 0404-9918; 0404-9917; 0409-1467; 52584-083; 0404-9919; 0406-3310; 71872-7114; 0409-1464; 52465-106; 52584-463; 62991-1546; 49452-4800; 51927-2140; 0406-3360
Synonyms Nalbuphine | Nalbuphine Hydrochloride | Nalbuphine Serb | EN-2234A | EN 2234A | EN2234A | Nubain
Chemical Information
Molecular Formula C21H28ClNO4
CAS Registry Number 23277-43-2
SMILES C1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hallucination19.10.02.002--
Headache17.14.01.001--
Hostility19.05.01.003--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Lacrimation increased06.08.02.004--
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Micturition urgency20.02.02.006--
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Piloerection23.02.06.005--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory distress22.02.01.012--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Rhinorrhoea22.02.05.010--
Sedation17.02.04.005--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
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