Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nalbuphine
Drug ID BADD_D01519
Description A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Indications and Usage For the relief of moderate to severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AF02
DrugBank ID DB00844
KEGG ID D08246
MeSH ID D009266
PubChem ID 5311304
TTD Drug ID D01KQA
NDC Product Code Not Available
Synonyms Nalbuphine | Nalbuphine Hydrochloride | Nalbuphine Serb | EN-2234A | EN 2234A | EN2234A | Nubain
Chemical Information
Molecular Formula C21H27NO4
CAS Registry Number 20594-83-6
SMILES C1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Injection site reaction12.07.03.015; 08.02.03.014--
Laryngeal oedema10.01.05.003; 23.04.01.005; 22.04.02.001--
Loss of consciousness17.02.04.004--Not Available
Micturition urgency20.02.02.006--
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Paraesthesia17.02.06.005--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Pulmonary oedema02.05.02.003; 22.01.03.003--
Rash23.03.13.001--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory distress22.02.01.012--Not Available
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Stridor22.04.02.003--
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Tremor17.01.06.002--
Urticaria10.01.06.001; 23.04.02.001--
The 2th Page    First    Pre   2 3    Next   Last    Total 3 Pages