Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Naftifine hydrochloride
Drug ID BADD_D01518
Description Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Indications and Usage Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftifine has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species including Candida albicans. However it is only used to treat the organisms listed in the indications.
Marketing Status Prescription
ATC Code D01AE22
DrugBank ID DB00735
KEGG ID D00883
MeSH ID C029178
PubChem ID 5281098
TTD Drug ID D00HPK
NDC Product Code 49706-0915; 0115-1510; 51672-1376; 70700-161; 17337-0531; 54766-772; 54766-770; 14501-0001; 0115-1512; 51672-1362; 51672-1368
Synonyms naftifine | naftifin | naftifine hydrochloride, (E)-isomer | naftifine hydrochloride | N-cinnamyl-N-methyl-1-naphthalenemethylamine hydrochloride
Chemical Information
Molecular Formula C21H22ClN
CAS Registry Number 65473-14-5
SMILES CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Erythema23.03.06.001--Not Available
Headache17.14.01.001--
Leukopenia01.02.02.001--Not Available
Pruritus23.03.12.001--
Scab23.03.03.004--Not Available
Skin irritation23.03.04.009--Not Available
Swelling08.01.03.015--Not Available
Skin maceration23.03.03.016--Not Available
Bloody discharge24.07.01.041; 08.01.03.039--Not Available
Inflammation08.01.05.007--Not Available
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