Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafcillin
Drug ID BADD_D01515
Description A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Indications and Usage Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Marketing Status Prescription; Discontinued
ATC Code J01CF06
DrugBank ID DB00607
KEGG ID D08242
MeSH ID D009254
PubChem ID 8982
TTD Drug ID D0A0JH
NDC Product Code 44567-221; 44567-223; 0409-3713; 0781-3126; 0781-9124; 44567-222; 0338-1017; 0338-1019; 0409-3714; 0409-3715; 0781-3124; 0781-9125; 0781-9126; 63323-330; 0781-3125
Synonyms Nafcillin | Naphthamidopenicillin | Nafcil | Nafcillin Sodium | Sodium, Nafcillin | Nafcillin, Monosodium Salt, Anhydrous | Sodium Nafcillin | Nafcillin, Sodium
Chemical Information
Molecular Formula C21H22N2O5S
CAS Registry Number 147-52-4
SMILES CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Peripheral swelling08.01.03.053; 02.05.04.0150.000213%Not Available
Staphylococcal bacteraemia11.02.05.0010.000056%Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Type IV hypersensitivity reaction10.01.03.0220.000532%Not Available
Transaminases increased13.03.01.0150.000213%Not Available
Inflammation08.01.05.007--Not Available
Ill-defined disorder08.01.03.049--Not Available
Renal impairment20.01.03.0100.000319%Not Available
Bone marrow failure01.03.03.005--
Soft tissue necrosis24.04.02.007; 15.03.02.002--
Acute kidney injury20.01.03.0160.001490%
Sensitisation10.02.01.012; 08.01.05.009--Not Available
Gastrointestinal tract irritation07.08.03.008--Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000194%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.000426%Not Available
Hepatic infarction24.04.07.007; 09.01.06.0170.000056%Not Available
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