Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nadolol
Drug ID BADD_D01512
Description Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adverse effects.[A34177] Nadolol was granted FDA approval on 10 December 1979.[L7922]
Indications and Usage Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.
Marketing Status Prescription; Discontinued
ATC Code C07AA12
DrugBank ID DB01203
KEGG ID D00432
MeSH ID D009248
PubChem ID 39147
TTD Drug ID D05SHK
NDC Product Code 68382-733; 72664-211; 51927-2776; 70518-1755; 70518-2139; 67787-348; 59762-0810; 27505-102; 0781-8006; 59762-0811; 51079-812; 76282-348; 68382-732; 68001-318; 69238-1124; 69238-1125; 42973-148; 76282-347; 70771-1090; 10135-687; 67787-349; 59762-0812; 0378-1132; 0781-8004; 0904-7070; 23155-732; 12780-0154; 76282-349; 0378-0028; 27505-101; 72664-212; 70771-1089; 27505-100; 0781-8005; 76385-135; 67787-347; 23155-730; 60687-302; 10135-686; 50787-0008; 59651-252; 71335-1972; 70771-1091; 69238-1123; 68001-317; 76385-133; 23155-731; 0378-1171; 59651-251; 68001-319; 78670-100; 60687-313; 10135-688; 63629-6942; 76385-134; 68382-734; 69575-4016; 72664-213; 71335-0697; 0904-7071; 69097-869; 69097-867; 69097-868; 78670-101; 65015-718; 51079-813
Synonyms Nadolol | SQ-11725 | SQ 11725 | SQ11725 | Corgard | Solgol
Chemical Information
Molecular Formula C17H27NO4
CAS Registry Number 1403-22-1
SMILES CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypotension24.06.03.0020.008334%
Insomnia19.02.01.002; 17.15.03.0020.001515%
Intermittent claudication24.04.03.001--Not Available
Irritability08.01.03.011; 19.04.02.013--
Ketoacidosis14.01.01.0080.009092%Not Available
Laryngospasm22.04.02.002--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Libido decreased21.03.02.005; 19.08.03.001--
Loss of consciousness17.02.04.004--Not Available
Mesenteric artery thrombosis24.01.08.003; 07.15.02.008--Not Available
Mood swings19.04.03.001--Not Available
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.001--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010--Not Available
Pain08.01.08.004--
Pancreatitis acute07.18.01.002--Not Available
Paraesthesia17.02.06.0050.001515%
Pemphigoid23.03.01.004; 10.04.02.002--Not Available
Peripheral coldness24.04.03.006; 08.01.09.0100.001515%Not Available
Peyronie's disease21.12.01.002--Not Available
Pruritus23.03.12.0010.002273%
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Respiratory distress22.02.01.012--Not Available
Sedation17.02.04.005--Not Available
Seizure17.12.03.0010.015153%
Shock24.06.02.002--Not Available
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