Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nadolol
Drug ID BADD_D01512
Description Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adverse effects.[A34177] Nadolol was granted FDA approval on 10 December 1979.[L7922]
Indications and Usage Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.
Marketing Status Prescription; Discontinued
ATC Code C07AA12
DrugBank ID DB01203
KEGG ID D00432
MeSH ID D009248
PubChem ID 39147
TTD Drug ID D05SHK
NDC Product Code 68382-733; 72664-211; 51927-2776; 70518-1755; 70518-2139; 67787-348; 59762-0810; 27505-102; 0781-8006; 59762-0811; 51079-812; 76282-348; 68382-732; 68001-318; 69238-1124; 69238-1125; 42973-148; 76282-347; 70771-1090; 10135-687; 67787-349; 59762-0812; 0378-1132; 0781-8004; 0904-7070; 23155-732; 12780-0154; 76282-349; 0378-0028; 27505-101; 72664-212; 70771-1089; 27505-100; 0781-8005; 76385-135; 67787-347; 23155-730; 60687-302; 10135-686; 50787-0008; 59651-252; 71335-1972; 70771-1091; 69238-1123; 68001-317; 76385-133; 23155-731; 0378-1171; 59651-251; 68001-319; 78670-100; 60687-313; 10135-688; 63629-6942; 76385-134; 68382-734; 69575-4016; 72664-213; 71335-0697; 0904-7071; 69097-869; 69097-867; 69097-868; 78670-101; 65015-718; 51079-813
Synonyms Nadolol | SQ-11725 | SQ 11725 | SQ11725 | Corgard | Solgol
Chemical Information
Molecular Formula C17H27NO4
CAS Registry Number 1403-22-1
SMILES CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.001515%
Adams-Stokes syndrome02.03.01.001; 17.02.04.010--Not Available
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Arrhythmia02.03.02.001--Not Available
Arterial thrombosis24.01.01.002--Not Available
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.003--
Atrioventricular block first degree02.03.01.004--
Atrioventricular block second degree02.03.01.0050.001515%
Blood pressure increased13.14.03.0050.002273%Not Available
Blood triglycerides increased13.12.03.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.002372%Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.0010.001581%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
Catatonia19.11.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Colitis ischaemic07.08.01.004; 24.04.08.012--Not Available
Completed suicide19.12.01.001; 08.04.01.0100.001384%Not Available
Conduction disorder02.03.01.008--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
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