Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Moxifloxacin
Drug ID BADD_D01501
Description Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Indications and Usage For the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
Marketing Status Prescription; Discontinued
ATC Code J01MA14; S01AE07
DrugBank ID DB00218
KEGG ID D08237
MeSH ID D000077266
PubChem ID 152946
TTD Drug ID D0ZV0Z
NDC Product Code 50090-3147; 0904-6406; 0378-5430; 65977-0038; 12527-0517; 17478-519; 72189-334; 72789-233; 50090-5279; 60505-0582; 67296-1679; 65862-840; 61919-553; 68180-422; 68180-421; 63629-8357; 72189-321; 72189-076; 55111-112
Synonyms Moxifloxacin | 1-Cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | Octegra | Proflox | Moxifloxacin Hydrochloride | Avelox | Avalox | Izilox | Actira | BAY 12-8039 | BAY 12 8039 | BAY-12-8039 | BAY 128039 | BAY-128039 | BAY128039
Chemical Information
Molecular Formula C21H24FN3O4
CAS Registry Number 151096-09-2
SMILES COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tendon rupture15.07.01.008; 12.01.07.0030.000578%Not Available
Tendonitis15.07.01.003; 12.01.07.0070.000578%Not Available
Tension headache17.14.01.004--Not Available
Throat tightness22.02.05.015; 19.01.02.0050.000868%Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Torsade de pointes02.03.04.005--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Tremor17.01.06.0020.000868%
Urticaria23.04.02.001; 10.01.06.0010.001157%
Vaginal infection11.01.10.002; 21.14.02.002--
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred17.17.01.010; 06.02.06.0070.002313%
Visual acuity reduced17.17.01.011; 06.02.03.0010.001735%
Visual impairment06.02.06.0080.000578%Not Available
Vomiting07.01.07.003--
Vulvovaginal candidiasis21.14.02.003; 11.03.03.005--Not Available
Wheezing22.03.01.009--
White blood cell count increased13.01.06.013--Not Available
Tubulointerstitial nephritis20.05.02.002--Not Available
Hypoacusis04.02.01.006--
Musculoskeletal chest pain22.09.01.001; 15.03.04.012--
Foreign body sensation in eyes06.01.01.0060.001157%Not Available
Platelet count increased13.01.04.002--Not Available
Conjunctival hyperaemia06.04.01.0040.000868%Not Available
Eyelids pruritus06.08.03.007; 23.03.12.0050.000578%Not Available
Eye oedema06.08.03.0130.001446%Not Available
Eye pruritus06.04.05.0060.001446%Not Available
Transaminases increased13.03.01.015--Not Available
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