Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Moxifloxacin
Drug ID BADD_D01501
Description Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Indications and Usage For the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
Marketing Status Prescription; Discontinued
ATC Code J01MA14; S01AE07
DrugBank ID DB00218
KEGG ID D08237
MeSH ID D000077266
PubChem ID 152946
TTD Drug ID D0ZV0Z
NDC Product Code 50090-3147; 0904-6406; 0378-5430; 65977-0038; 12527-0517; 17478-519; 72189-334; 72789-233; 50090-5279; 60505-0582; 67296-1679; 65862-840; 61919-553; 68180-422; 68180-421; 63629-8357; 72189-321; 72189-076; 55111-112
Synonyms Moxifloxacin | 1-Cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | Octegra | Proflox | Moxifloxacin Hydrochloride | Avelox | Avalox | Izilox | Actira | BAY 12-8039 | BAY 12 8039 | BAY-12-8039 | BAY 128039 | BAY-128039 | BAY128039
Chemical Information
Molecular Formula C21H24FN3O4
CAS Registry Number 151096-09-2
SMILES COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Death08.04.01.001--
Dehydration14.05.05.001--
Delirium19.13.02.0010.000868%
Depression19.15.01.001--
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drug hypersensitivity10.01.01.0010.001157%Not Available
Dry eye06.08.02.0010.000578%
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.0060.000578%
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.0020.001735%
Dysuria20.02.02.002--
Electrocardiogram QT prolonged13.14.05.004--
Endophthalmitis11.01.06.003; 06.04.05.0090.002024%
Eosinophil count decreased13.01.06.003--Not Available
Eosinophil count increased13.01.06.004--Not Available
Eosinophilia01.02.04.001--
Erythema23.03.06.0010.002603%Not Available
Erythema of eyelid23.03.06.006; 06.04.04.0030.000868%Not Available
Eye allergy10.01.03.028; 06.04.05.0100.000868%Not Available
Eye discharge06.04.05.0010.001446%Not Available
Eye infection11.01.06.001; 06.04.05.0070.000868%
Eye inflammation06.04.05.0020.000578%Not Available
Eye irritation06.04.05.0030.003470%Not Available
Eye pain06.08.03.0020.003759%
Eye swelling06.08.03.0030.002024%Not Available
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