Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Molindone
Drug ID BADD_D01487
Description An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)
Indications and Usage Molindone is used for the management of the manifestations of psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AE02
DrugBank ID DB01618
KEGG ID D08226
MeSH ID D008972
PubChem ID 23897
TTD Drug ID D09TPF
NDC Product Code Not Available
Synonyms Molindone | Moban | Molindone Hydrochloride | Hydrochloride, Molindone | Molindone Monohydrochloride | Monohydrochloride, Molindone
Chemical Information
Molecular Formula C16H24N2O2
CAS Registry Number 7416-34-4
SMILES CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Akathisia19.06.02.006; 17.01.02.002--
Akinesia17.01.02.003--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Euphoric mood19.04.02.006--
Extrapyramidal disorder17.01.02.007--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Hyperkinesia17.01.02.008--Not Available
Hypotension24.06.03.002--
Immobile26.01.01.002--Not Available
Lenticular opacities06.06.01.003--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Libido increased21.03.02.007; 19.08.03.002--
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Priapism21.03.01.005--Not Available
Protrusion tongue17.02.05.037; 07.14.02.002--Not Available
Rash23.03.13.001--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Surgery25.01.02.003--Not Available
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