Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Moexipril hydrochloride
Drug ID BADD_D01485
Description Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Indications and Usage For the treatment of hypertension.
Marketing Status Prescription; Discontinued
ATC Code C09AA13
DrugBank ID DB00691
KEGG ID D00623
MeSH ID C058302
PubChem ID 54889
TTD Drug ID D00HDU
NDC Product Code 0093-5150; 17404-0018; 68462-208; 0093-0017; 68462-209; 66039-838
Synonyms moexipril | 2-((1-ethoxycarbony)-3-phenylpropylamino-1-oxopropyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | Fempress | moexipril hydrochloride | Univasc | Moex | Perdix | RS 10085 | RS-10085
Chemical Information
Molecular Formula C27H35ClN2O7
CAS Registry Number 82586-52-5
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC(=C(C=C3CC2C(=O)O)OC)OC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Blood pressure decreasedAngiotensin-converting enzymeP12821T82577Not Available
CoughB2 bradykinin receptorP30411T23714Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Blood creatine increased13.13.01.001--Not Available
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Eosinophilic pneumonia22.01.01.004; 01.02.04.003--Not Available
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperkalaemia14.05.03.001--
Hyponatraemia14.05.04.002--
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