| Pharmaceutical Information |
| Drug Name |
Mitotane |
| Drug ID |
BADD_D01479 |
| Description |
A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. |
| Indications and Usage |
For treatment of inoperable adrenocortical tumours; Cushing's syndrome |
| Marketing Status |
Prescription |
| ATC Code |
L01XX23 |
| DrugBank ID |
DB00648
|
| KEGG ID |
D00420
|
| MeSH ID |
D008939
|
| PubChem ID |
4211
|
| TTD Drug ID |
D0Z5OE
|
| NDC Product Code |
62991-2604; 38779-2263; 21222-002; 14799-2009; 51927-3826; 49452-4786; 43744-366; 72969-051; 71052-048; 76336-080 |
| Synonyms |
Mitotane | o,p-DDD | Mytotan | ortho,para-DDD | ortho,para DDD | Chlodithane | Lysodren | Chloditan | Khloditan |
|
| Chemical Information |
| Molecular Formula |
C14H10Cl4 |
| CAS Registry Number |
53-19-0 |
| SMILES |
C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Ovarian cyst ruptured | 21.11.01.015; 16.04.03.006 | 0.000533% | | Not Available |
|
|
|
