Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mitotane
Drug ID BADD_D01479
Description A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Indications and Usage For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Marketing Status Prescription
ATC Code L01XX23
DrugBank ID DB00648
KEGG ID D00420
MeSH ID D008939
PubChem ID 4211
TTD Drug ID D0Z5OE
NDC Product Code 62991-2604; 38779-2263; 21222-002; 14799-2009; 51927-3826; 49452-4786; 43744-366; 72969-051; 71052-048; 76336-080
Synonyms Mitotane | o,p-DDD | Mytotan | ortho,para-DDD | ortho,para DDD | Chlodithane | Lysodren | Chloditan | Khloditan
Chemical Information
Molecular Formula C14H10Cl4
CAS Registry Number 53-19-0
SMILES C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vertigo17.02.12.002; 04.04.01.0030.000533%
Vision blurred17.17.01.010; 06.02.06.0070.000533%
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.0030.000533%
Retinal toxicity12.03.01.036; 06.09.03.013--Not Available
Balance disorder17.02.02.007--Not Available
Lymphatic disorder01.09.01.003--Not Available
Protein urine present13.13.02.006--Not Available
Epigastric discomfort07.01.02.004--Not Available
Growth retardation15.03.01.006--
Gastrointestinal toxicity12.03.01.019; 07.08.03.0060.001598%Not Available
Angiopathy24.03.02.007--Not Available
Skin toxicity23.03.03.032; 12.03.01.020--Not Available
Blood alkaline phosphatase increased13.04.02.0040.000533%
Hepatic enzyme increased13.03.01.019--Not Available
Breast disorder21.05.04.004--Not Available
Connective tissue disorder15.06.01.006--Not Available
Haematotoxicity12.03.01.025; 01.05.01.0070.000533%Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.000533%
Blood disorder01.05.01.004--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Orthostatic hypertension24.08.02.010; 17.05.01.018--Not Available
Liver injury12.01.02.003; 09.01.07.022--Not Available
Brain injury19.07.03.007; 17.11.01.003--Not Available
Cholestatic liver injury09.01.07.0160.000533%Not Available
Intellectual disability19.21.06.001; 17.03.07.001--Not Available
Mineralocorticoid deficiency14.11.01.033; 05.01.02.010--Not Available
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