Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mitotane
Drug ID BADD_D01479
Description A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Indications and Usage For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Marketing Status approved
ATC Code L01XX23
DrugBank ID DB00648
KEGG ID D00420
MeSH ID D008939
PubChem ID 4211
TTD Drug ID D0Z5OE
NDC Product Code 71052-048; 76336-080; 62991-2604; 14799-2009; 38779-2263; 21222-002; 49452-4786
UNII 78E4J5IB5J
Synonyms Mitotane | o,p-DDD | Mytotan | ortho,para-DDD | ortho,para DDD | Chlodithane | Lysodren | Chloditan | Khloditan
Chemical Information
Molecular Formula C14H10Cl4
CAS Registry Number 53-19-0
SMILES C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000280%
Aggression19.05.01.001--Not Available
Albuminuria20.02.01.001--Not Available
Amenorrhoea05.05.01.002; 21.01.02.0010.000168%
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Asthenia08.01.01.0010.000168%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Autoimmune hepatitis10.04.09.001; 09.01.07.019--Not Available
Bleeding time prolonged13.01.02.002--Not Available
Blood cholesterol increased13.12.01.002--
Blood triglycerides increased13.12.03.001--Not Available
Blood uric acid decreased13.02.04.004--Not Available
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000112%Not Available
Cataract06.06.01.001--
Confusional state17.02.03.005; 19.13.01.001--
Cystitis haemorrhagic20.03.02.003--Not Available
Death08.04.01.0010.000504%
Depression19.15.01.0010.000246%
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Diarrhoea07.02.01.0010.000302%
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.0030.000548%
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.001--
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