Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mitotane
Drug ID BADD_D01479
Description A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Indications and Usage For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Marketing Status Prescription
ATC Code L01XX23
DrugBank ID DB00648
KEGG ID D00420
MeSH ID D008939
PubChem ID 4211
TTD Drug ID D0Z5OE
NDC Product Code 62991-2604; 38779-2263; 21222-002; 14799-2009; 51927-3826; 49452-4786; 43744-366; 72969-051; 71052-048; 76336-080
Synonyms Mitotane | o,p-DDD | Mytotan | ortho,para-DDD | ortho,para DDD | Chlodithane | Lysodren | Chloditan | Khloditan
Chemical Information
Molecular Formula C14H10Cl4
CAS Registry Number 53-19-0
SMILES C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Adrenal insufficiency05.01.02.001; 14.11.01.0040.001066%
Aggression19.05.01.001--Not Available
Albuminuria20.02.01.001--Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Asthenia08.01.01.0010.000799%Not Available
Ataxia08.01.02.004; 17.02.02.001--
Autoimmune hepatitis10.04.09.001; 09.01.07.019--Not Available
Bleeding time prolonged13.01.02.0020.001332%Not Available
Blood cholesterol increased13.12.01.002--
Blood triglycerides increased13.12.03.001--Not Available
Blood uric acid decreased13.02.04.004--Not Available
Body temperature increased13.15.01.001--Not Available
Cataract06.06.01.001--
Confusional state19.13.01.001; 17.02.03.005--
Cystitis haemorrhagic20.03.02.003--Not Available
Death08.04.01.0010.000625%
Depression19.15.01.0010.000533%
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.0070.001332%
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.0020.000533%
Encephalopathy17.13.02.001--
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