Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Minocycline
Drug ID BADD_D01470
Description Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.[A190723] Minocycline was granted FDA approval on 30 June 1971.[L11695]
Indications and Usage For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Marketing Status Prescription; Discontinued
ATC Code A01AB23; D10AF07; J01AA08
DrugBank ID DB01017
KEGG ID D05045
MeSH ID D008911
PubChem ID 54675783
TTD Drug ID D08LTU
NDC Product Code 42291-591; 42291-589; 69489-201; 72356-101; 49884-512; 72356-103; 63629-2228; 49884-513; 63629-2229; 49884-511
Synonyms Minocycline | Minox 50 | Aknemin | Aknin-Mino | Aknin Mino | Aknosan | Mynocine | Apo-Minocycline | Apo Minocycline | Arestin | Blemix | Cyclomin | Cyclops | Dentomycin | Dynacin | Icht-Oral | Icht Oral | Klinomycin | Lederderm | Mestacine | Minakne | Mino-Wolff | Mino Wolff | Minocin | Minocin MR | Minoclir | Minocycline Hydrochloride | Hydrochloride, Minocycline | Minocycline Monohydrochloride | Monohydrochloride, Minocycline | Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer | Minolis | Minomycin | Minoplus | Minotab | Akamin | Akne-Puren | Akne Puren
Chemical Information
Molecular Formula C23H27N3O7
CAS Registry Number 10118-90-8
SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2E1P05181Not Available1421660; 3224399; 1814842
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscular weakness17.05.03.005; 15.05.06.0010.003624%
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.0010.006990%
Myelopathy17.10.01.0070.000777%Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocarditis02.04.03.0010.001486%
Myopathy15.05.05.0010.000518%Not Available
Nail discolouration23.02.05.0010.002071%
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nephritis20.05.02.001--Not Available
Neuropathy peripheral17.09.03.0030.009579%Not Available
Neutropenia01.02.03.004--Not Available
Neutrophilia01.02.01.0050.000777%Not Available
Night sweats23.02.03.006; 08.01.03.0310.001812%Not Available
Nipple pain21.05.05.0090.000518%Not Available
Normochromic normocytic anaemia01.03.02.0050.000777%Not Available
Odynophagia07.05.03.0010.000518%Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Oesophageal ulcer07.04.05.002--
Oesophageal varices haemorrhage24.07.02.022; 09.01.06.004; 07.12.01.0030.000203%
Oesophagitis07.08.05.001--
Optic atrophy06.09.02.0010.001294%Not Available
Oral mucosal discolouration07.05.05.0070.000518%Not Available
Oral pain07.05.03.0020.000518%
Orchitis21.09.02.002; 11.01.19.0040.000518%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.0200.000777%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.01.02.003--
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