Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Minocycline
Drug ID BADD_D01470
Description Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.[A190723] Minocycline was granted FDA approval on 30 June 1971.[L11695]
Indications and Usage For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Marketing Status Prescription; Discontinued
ATC Code A01AB23; D10AF07; J01AA08
DrugBank ID DB01017
KEGG ID D05045
MeSH ID D008911
PubChem ID 54675783
TTD Drug ID D08LTU
NDC Product Code 42291-591; 42291-589; 69489-201; 72356-101; 49884-512; 72356-103; 63629-2228; 49884-513; 63629-2229; 49884-511
Synonyms Minocycline | Minox 50 | Aknemin | Aknin-Mino | Aknin Mino | Aknosan | Mynocine | Apo-Minocycline | Apo Minocycline | Arestin | Blemix | Cyclomin | Cyclops | Dentomycin | Dynacin | Icht-Oral | Icht Oral | Klinomycin | Lederderm | Mestacine | Minakne | Mino-Wolff | Mino Wolff | Minocin | Minocin MR | Minoclir | Minocycline Hydrochloride | Hydrochloride, Minocycline | Minocycline Monohydrochloride | Monohydrochloride, Minocycline | Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer | Minolis | Minomycin | Minoplus | Minotab | Akamin | Akne-Puren | Akne Puren
Chemical Information
Molecular Formula C23H27N3O7
CAS Registry Number 10118-90-8
SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2E1P05181Not Available1421660; 3224399; 1814842
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aortic valve disease02.07.03.0020.000777%
Conjunctival pigmentation06.06.02.0100.002589%Not Available
Inflammatory marker increased13.09.02.0030.000518%Not Available
Type 1 lepra reaction10.01.03.047; 23.09.01.024; 17.09.03.024; 11.04.03.0030.000518%Not Available
Type 2 lepra reaction24.05.02.026; 23.07.02.006; 11.04.03.004; 10.01.03.0480.000777%Not Available
Bone hyperpigmentation15.02.04.0300.009579%Not Available
Oral pigmentation07.05.05.0240.000518%Not Available
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