Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Midodrine hydrochloride
Drug ID BADD_D01462
Description An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Indications and Usage For the treatment of symptomatic orthostatic hypotension (OH).
Marketing Status Prescription; Discontinued
ATC Code C01CA17
DrugBank ID DB00211
KEGG ID D01307
MeSH ID D008879
PubChem ID 18340
TTD Drug ID D02XJY
NDC Product Code 70700-158; 70700-157; 42291-560; 72888-112; 50268-563; 0904-6817; 0245-0213; 0615-8293; 68382-738; 72888-113; 71335-1433; 62332-338; 51407-390; 60687-398; 70985-007; 0378-1902; 63190-0080; 64980-434; 0245-0212; 72888-114; 70700-159; 0615-8291; 14593-917; 63629-2348; 52817-323; 0615-8384; 63629-7983; 70985-005; 63629-2227; 0615-8382; 63629-2347; 70771-1595; 46708-339; 0615-8383; 59651-248; 55154-8086; 62332-339; 42291-562; 51407-388; 46708-338; 60687-387; 71205-905; 49884-849; 68382-739; 64980-435; 51407-389; 49884-874; 42291-561; 59651-247; 55154-5623; 59651-246; 63629-2346; 62332-340; 60505-1320; 50268-562; 70771-1596; 71205-904; 0378-1903; 52817-325; 66583-0509; 71205-906; 71335-1705; 51079-453; 68382-737; 0904-6818; 49884-814; 60687-409; 70054-004; 60505-1321; 59285-043; 57451-1204; 60505-1325; 70985-006; 50268-561; 70771-1597; 64980-433; 0245-0211; 50384-0800; 63190-0720; 55154-5696; 0378-1901; 50384-0810; 0904-6819; 46708-340; 63629-6928; 52817-324; 63190-0580
Synonyms Midodrine | Midodrin | Midodrine Hydrochloride | Midodrine Monohydrochloride | Monohydrochloride, Midodrine | ProAmatine | Amatine | ST-1085 | ST 1085 | ST1085 | Gutron | Midon
Chemical Information
Molecular Formula C12H19ClN2O4
CAS Registry Number 43218-56-0
SMILES COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Anxiety19.06.02.002--
Aphthous ulcer07.05.06.002--Not Available
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Chills15.05.03.016; 08.01.09.001--
Confusional state17.02.03.005; 19.13.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dyspepsia07.01.02.001--
Dysuria20.02.02.002--
Erythema multiforme23.03.01.003; 10.01.03.015--
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Head discomfort17.02.05.027--Not Available
Headache17.14.01.001--
Hyperaesthesia17.02.06.004--Not Available
Hypertension24.08.02.001--
Insomnia19.02.01.002; 17.15.03.002--
Micturition urgency20.02.02.006--
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Piloerection23.02.06.005--Not Available
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
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