| Drug Name |
Midazolam |
| Drug ID |
BADD_D01459 |
| Description |
Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties.[A173842] It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.[A173842] Midazolam is available by oral, rectal, intranasal, intramuscular (IM), and intravenous (IV) routes and has been used in various biomedical applications, including dentistry, cardiac surgery, and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.[F2977]
This drug was initially approved by the US FDA in 1985, and has been approved for various indications since.[FDA label] In late 2018, the intramuscular preparation was approved by the FDA for the treatment of status epilepticus in adults.[FDA label] In May 2019, the nasal spray of midazolam was approved for the acute treatment of distinctive intermittent, stereotypic seizure episodes in patients 12 years of age and older. Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.[L5074] |
| Indications and Usage |
The midazolam injection is indicated for preoperative sedation/anziolysis/amnesia. It is also an agent for sedation/anziolysis/amnesia prior to or during diagnostic, therapeutic, or endoscopic procedures. Midazolam can also be given intravenously for induction of general anaesthesia. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
N05CD08 |
| DrugBank ID |
DB00683
|
| KEGG ID |
D00550
|
| MeSH ID |
D008874
|
| PubChem ID |
4192
|
| TTD Drug ID |
D0U6LM
|
| NDC Product Code |
0404-9912; 72611-749; 79037-001; 52584-596; 0641-6057; 0404-9915; 72611-741; 52584-059; 82393-117; 72572-432; 48087-0098; 50090-0683; 51552-1023; 72572-430; 0404-9913; 0641-6060; 0641-6210; 0641-6059; 0641-6063; 52584-081; 17511-115; 67763-100; 0641-6211; 0641-6061; 0641-6209; 12828-0069; 0641-6056; 51927-0001; 0641-6190; 50090-0738; 63275-9925; 38779-2684; 50474-500; 49452-4721 |
| Synonyms |
Midazolam | Midazolam Maleate | Maleate, Midazolam | Dormicum | Versed | Midazolam Hydrochloride | Hydrochloride, Midazolam | Ro 21-3981 | Ro 21 3981 | Ro 213981 |
