Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mexiletine
Drug ID BADD_D01452
Description Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Indications and Usage For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.
Marketing Status Prescription; Discontinued
ATC Code C01BB02
DrugBank ID DB00379
KEGG ID D08215
MeSH ID D008801
PubChem ID 4178
TTD Drug ID D0X0RI
NDC Product Code Not Available
Synonyms Mexiletine | Novo-Mexiletine | Novo Mexiletine | Mexiletine Hydrochloride | Mexitil | Mexitil PL | Mexityl | KO-1173 | KO 1173 | KO1173 | KOE-1173 | KOE 1173 | KOE1173 | Mexiletene
Chemical Information
Molecular Formula C11H17NO
CAS Registry Number 31828-71-4
SMILES CC1=C(C(=CC=C1)C)OCC(C)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Toxicity to various agentsCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oesophageal ulcer07.04.05.002--
Pain08.01.08.004--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pulmonary fibrosis22.01.02.006--
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Shock24.06.02.002--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tension19.06.02.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Upper gastrointestinal haemorrhage24.07.02.024; 07.12.02.006--
Urinary hesitation20.02.02.009--Not Available
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Musculoskeletal discomfort15.03.04.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Antinuclear antibody positive13.06.01.003--Not Available
The 3th Page    First    Pre   3 4    Next   Last    Total 4 Pages