Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Metronidazole
Drug ID BADD_D01449
Description Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics.[L3754] It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A18039] Metronidazole has been used as an antibiotic for several decades[L7429], with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
Indications and Usage Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis[L7432], certain types of amebiasis, and various anaerobic infections.[A181057] The above anaerobic infections may occur on the skin and skin structures, the abdomen, the heart, reproductive organs, central nervous system, and the respiratory system. Some may also be present in the bloodstream in cases of septicemia. Common infections treated by metronidazole are Bacteroides species infections, Clostridium infections, and Fusobacterium infections, as well as Peptococcus and Peptostreptococcus infections.[L3754] It is also used off-label in the treatment of Crohn's disease and rosacea, as a prophylactic agent after surgery[A181039], and in the treatment of Helicobacter pylori infection.[A181045] It has also been studied in the prevention of preterm births and to treat periodontal disease.[A1391,A181078]
Marketing Status approved
ATC Code A01AB17; D06BX01; G01AF01; J01XD01; P01AB01
DrugBank ID DB00916
KEGG ID D00409
MeSH ID D008795
PubChem ID 4173
TTD Drug ID D0A2ZX
NDC Product Code 80830-2465; 0904-7156; 23155-652; 50090-0211; 50090-4809; 50111-333; 51407-372; 62332-018; 66993-962; 67296-1366; 68071-2549; 0409-0152; 68180-684; 68682-455; 69292-208; 70518-0013; 70518-0539; 70518-2663; 70518-3042; 70771-1834; 71335-1775; 46708-428; 46708-429; 0187-5202; 50090-0212; 50090-0214; 50090-5691; 51407-376; 60687-550; 63629-1388; 63629-8731; 68788-7815; 70518-3265; 72578-008; 72578-129; 0713-0633; 0904-7126; 38779-0146; 62991-1685; 25021-131; 29300-227; 45802-139; 46708-435; 50090-5687; 51672-4164; 0264-5535; 55154-8190; 55700-909; 0299-3836; 0338-9541; 63187-035; 63629-7940; 64380-780; 64980-235; 66993-936; 68071-2806; 70518-1240; 70518-3110; 71335-1681; 54348-740; 60687-526; 62332-016; 63187-827; 66993-960; 68071-2809; 68071-5283; 68462-184; 70518-2305; 70518-2814; 70934-813; 71209-063; 71335-1609; 71335-1703; 71335-1838; 72578-007; 16714-557; 45865-717; 50090-5787; 51655-441; 55700-298; 61919-032; 62332-017; 67457-697; 68001-364; 68180-683; 72789-007; 72789-195; 15955-388; 16571-664; 0115-1474; 43063-738; 0168-0383; 50090-5688; 50268-534; 0245-0860; 53002-2478; 58118-0527; 0299-3820; 0338-1055; 64980-236; 65862-694; 67296-1283; 0404-9991; 68071-2251; 0409-7811; 68788-8230; 70518-0090; 70882-131; 0781-7077; 0781-7080; 51927-1449; 53747-007; 60592-427; 68981-034; 23155-651; 53002-2470; 0299-3838; 60760-539; 61919-499; 63629-1386; 63629-7916; 64380-779; 68788-7955; 70518-1536; 70518-3073; 71335-0358; 71335-1922; 0713-0575; 0713-0637; 49452-4726; 49964-0002; 51552-0038; 43063-719; 50090-5768; 50111-334; 50268-535; 51672-4116; 52584-811; 53002-7341; 63629-8680; 68083-373; 69043-005; 70518-0797; 70882-130; 71335-0858; 72789-011; 0642-7466; 73473-303; 0713-0574; 82982-039; 0395-8115; 15955-389; 21922-039; 47335-993; 50090-0213; 50090-5249; 51655-974; 54348-745; 60760-336; 67296-1747; 69043-004; 70518-0324; 70934-970; 71209-062; 72789-005; 16571-665; 29300-226; 46708-021; 53002-7340; 60760-664; 61919-363; 62332-630; 63187-511; 65862-695; 66993-961; 68001-365; 68071-2280; 68071-2288; 68071-2551; 68071-3039; 69292-207; 70518-0058; 70518-0088; 70518-1241; 70934-956; 0168-0275; 0168-0323; 50090-0201; 50090-2126; 51672-4215; 53002-2471; 0025-1942
UNII 140QMO216E
Synonyms Metronidazole | 2-Methyl-5-nitroimidazole-1-ethanol | 2 Methyl 5 nitroimidazole 1 ethanol | Satric | Trichazol | Trichopol | Trivazol | Metronidazole Phosphoester | Vagilen | Bayer 5360 | Metronidazole Phosphate | Danizol | Flagyl | Gineflavir | Metric | Metrodzhil | MetroGel | Metrogyl | Metronidazole Hydrochloride | Metronidazole Monohydrochloride | Clont
Chemical Information
Molecular Formula C6H9N3O3
CAS Registry Number 443-48-1
SMILES CC1=NC=C(N1CCO)[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lymphomatoid papulosis23.03.08.0110.000066%Not Available
Pharyngeal hypoaesthesia22.04.05.017; 17.02.06.0340.000026%Not Available
Cerebellar haematoma24.07.04.022; 17.08.01.0450.000026%Not Available
Fear of death19.06.03.0060.000026%Not Available
Fistula discharge15.03.02.015; 08.01.03.0690.000039%Not Available
Oral mucosal erythema07.05.05.0230.000026%Not Available
Skin plaque23.03.03.0440.000026%Not Available
Frontotemporal dementia19.20.02.008; 17.03.01.0070.000053%Not Available
Ovarian vein thrombosis21.11.02.019; 24.01.05.0120.000026%Not Available
Penile burning sensation21.12.01.0150.000026%Not Available
Skin texture abnormal23.03.03.0680.000026%Not Available
Toxic leukoencephalopathy17.13.02.012; 12.03.01.0590.000131%Not Available
Nodular rash23.03.13.0210.000105%Not Available
Cutaneous T-cell dyscrasia01.05.01.020; 23.03.03.0630.000026%Not Available
Alien limb syndrome19.21.01.010; 17.01.02.0270.000026%Not Available
Anterior interosseous syndrome17.09.02.0180.000053%Not Available
Bell's palsy17.04.03.0110.000053%Not Available
Cellulite23.07.04.0280.000026%Not Available
Cytotoxic lesions of corpus callosum17.02.10.030; 12.03.01.0620.000053%Not Available
Drug ineffective for unapproved indication12.09.02.002; 08.06.01.0380.000680%Not Available
Dysbiosis12.02.05.053; 07.11.01.0340.000026%Not Available
Dysdiadochokinesis17.02.02.0180.000171%Not Available
Eye symptom17.17.02.015; 06.08.03.027--Not Available
Fixed eruption23.03.05.008; 10.01.01.037; 08.01.06.0250.000528%Not Available
Gait inability17.02.05.069; 08.01.02.0110.000118%Not Available
Gut fermentation syndrome07.11.01.0390.000039%Not Available
Haemophagocytic lymphohistiocytosis16.32.03.038; 10.02.01.077; 01.05.01.0260.000039%Not Available
Heavy menstrual bleeding21.01.03.005--Not Available
Hepatic cytolysis09.01.07.0360.000079%Not Available
Hyperintensity in brain deep nuclei17.11.01.0210.000039%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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