Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoprolol succinate
Drug ID BADD_D01446
Description Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
Indications and Usage For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Marketing Status Discontinued; Prescription
ATC Code C07AB02
DrugBank ID DB00264
KEGG ID D00635
MeSH ID D008790
PubChem ID 62937
TTD Drug ID D0I2MK
NDC Product Code 68001-119; 60050-002; 24979-039; 45963-678; 68001-120; 67544-491; 53296-0058; 68788-7718; 60050-004; 75834-291; 50742-618; 52932-0713; 72640-015; 51407-403; 17228-7303; 68001-122; 55154-7280; 31722-592; 57451-1147; 71335-0158; 50742-616; 71610-558; 68382-566; 0378-4598; 51407-404; 50090-5413; 45963-677; 63304-011; 68001-469; 68645-478; 63629-8100; 51079-169; 63187-546; 53002-1612; 50090-3808; 68071-2455; 55154-4698; 71205-336; 46708-906; 50090-5411; 63304-009; 64679-735; 55111-469; 71610-642; 61919-754; 64679-736; 50090-5393; 70771-1341; 50090-4304; 75834-290; 51655-615; 70518-2953; 43063-841; 68382-567; 60050-001; 50268-542; 71335-1951; 10631-010; 70518-3122; 45963-676; 65862-415; 67544-555; 68071-2651; 71610-484; 50090-3896; 50268-543; 70771-1340; 70771-1339; 64679-846; 0615-7824; 71610-483; 16714-852; 60760-492; 45963-709; 10631-008; 68071-2522; 68071-5282; 68001-357; 12666-0002; 17228-0109; 70934-725; 14445-022; 63187-768; 71610-555; 70518-2310; 10631-009; 64679-848; 68071-4377; 17228-7301; 67296-1720; 55111-467; 68788-8069; 50090-4904; 70518-2133; 68071-1922; 69097-408; 0378-4596; 55111-468; 68071-1921; 70518-3062; 60760-493; 68645-479; 68788-7997; 70518-2770; 24979-038; 50090-5053; 0378-4597; 24979-037; 31722-591; 70347-100; 55154-6886; 72789-107; 0615-7823; 71610-373; 68645-477; 53002-1781; 71335-1273; 16714-855; 70518-3143; 50090-5394; 71610-573; 68788-7206; 17228-1088; 50090-5419; 71610-035; 50090-5418; 55700-232; 49587-114; 71335-0786; 50090-2296; 70518-0391; 51407-405; 72789-145; 71335-0809; 75834-292; 63629-7153; 62732-1047; 69097-409; 68001-360; 63304-008; 68001-358; 64679-847; 31722-589; 71205-350; 68071-2331; 71335-0864; 51407-406; 63629-8237; 60760-635; 60687-413; 68001-471; 68071-2191; 68001-470; 68382-564; 50268-541; 63187-547; 16714-853; 55700-253; 31722-590; 16714-854; 71205-162; 51079-170; 50090-3847; 71335-0149; 51655-203; 75834-293; 0904-6324; 50090-5392; 68788-7263; 68071-4363; 61919-334; 43063-624; 55700-192; 71610-509; 17228-0111; 64679-849; 0615-7825; 70347-200; 55111-851; 43063-663; 60687-402; 68382-565; 24979-040; 70347-050; 71335-1875; 60687-390; 0904-6322; 42419-003; 51079-171; 17228-0110; 0378-4595; 10631-011; 70518-3164; 63187-545; 71610-161; 71610-512; 71205-179; 50742-615; 71335-1878; 63304-010; 71335-0167; 71610-496; 17228-7302; 0904-6323; 64679-737; 69097-407; 50090-5395; 64679-734; 67544-282; 50090-4902; 68001-356; 60050-003; 67321-509; 50090-3746; 63415-0012; 68001-121; 60760-616; 70436-183; 50742-617; 68071-4351; 60760-634; 70436-166; 68788-8098; 51655-569; 70771-1338; 67296-1149; 50090-5950; 50268-540; 55154-7279; 55111-466; 70518-2868; 71610-038; 62732-1046; 70436-167; 51655-597; 50090-5412; 72789-010; 71205-368; 70347-025; 17228-7300
Synonyms Metoprolol | Toprol | Betaloc | Betaloc-Astra | Betaloc Astra | Betalok | CGP-2175 | CGP 2175 | CGP2175 | H 93-26 | H 93 26 | H 9326 | Metoprolol Tartrate | Seloken | Spesicor | Spesikor | Metoprolol Succinate | Metoprolol CR-XL | Metoprolol CR XL | Toprol-XL | Toprol XL | Beloc-Duriles | Beloc Duriles | Lopressor
Chemical Information
Molecular Formula C34H56N2O10
CAS Registry Number 98418-47-4
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Accident12.01.08.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Blood alkaline phosphatase13.04.02.010--Not Available
Blood lactate dehydrogenase13.04.02.009--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Catatonia19.11.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Death08.04.01.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Hallucination19.10.02.002--
Headache17.14.01.001--
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