Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoprolol succinate
Drug ID BADD_D01446
Description Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
Indications and Usage Metoprolol is indicated for the treatment of angina, heart failure, myocardial infarction, atrial fibrillation, atrial flutter and hypertension.[A175141] Some off-label uses of metoprolol include supraventricular tachycardia and thyroid storm.[A175141] All the indications of metoprolol are part of cardiovascular diseases. These conditions correspond to a number of diseases that involve the function of the heart and blood vessels. The underlying causes of these conditions are variable and can be due to genetic disposition, lifestyle decisions such as smoking, obesity, diet, and lack of exercise, and comorbidity with other conditions such as diabetes. The cardiovascular diseases are the leading cause of death on a global scale.[L5533]
Marketing Status approved; investigational
ATC Code C07AB02
DrugBank ID DB00264
KEGG ID D00635
MeSH ID D008790
PubChem ID 62937
TTD Drug ID D0I2MK
NDC Product Code 82009-113; 17228-7303; 49587-114; 67321-509; 75834-291; 31722-590; 45963-677; 50268-540; 60687-413; 60760-493; 63304-008; 0378-4597; 67544-491; 68071-5282; 68382-566; 68645-479; 69097-407; 69097-409; 70347-050; 70842-112; 70842-113; 70934-388; 71610-035; 0615-7825; 72516-030; 75834-290; 17228-7300; 10631-010; 16714-852; 16714-853; 45963-676; 50090-3808; 50090-5392; 50742-615; 50742-617; 50816-025; 51079-171; 51655-597; 51655-615; 55154-4698; 60760-563; 0378-4595; 68001-358; 68001-469; 70436-166; 70518-0391; 71205-162; 71205-368; 72603-142; 72789-010; 72789-145; 60050-002; 65862-415; 31722-589; 31722-591; 50090-5950; 50090-6484; 51407-405; 55154-7280; 60687-402; 63304-009; 68645-478; 70518-2080; 71205-683; 71205-724; 71205-800; 71610-558; 55111-466; 60760-634; 61919-754; 0378-4596; 0378-4598; 68001-119; 68001-357; 68645-477; 70518-3164; 70518-3545; 71205-179; 71205-801; 71335-1951; 72789-107; 72789-284; 82009-114; 12666-0002; 14445-022; 17228-7302; 50090-4904; 51655-193; 53002-2612; 55154-6886; 63187-546; 63629-9413; 68001-360; 68788-8069; 70436-167; 70436-183; 70518-2133; 70771-1339; 71205-336; 71335-1875; 71610-038; 0615-7823; 72516-031; 60050-004; 10631-009; 10631-011; 72640-015; 45963-678; 50090-6448; 50090-6487; 51079-169; 55111-469; 55700-192; 63187-768; 68788-8486; 70347-025; 70436-202; 70518-2953; 70771-1338; 70771-1341; 70934-267; 71335-0149; 71335-9749; 71610-555; 72603-143; 0904-6322; 0904-6324; 63415-0012; 75834-292; 45963-709; 50090-6488; 50816-050; 50816-200; 63187-545; 68001-120; 68001-356; 68001-471; 68788-7997; 68788-8448; 70518-2770; 70518-3062; 70518-3122; 71335-0167; 60050-001; 10631-008; 31722-592; 43063-624; 43063-841; 50090-4902; 50090-6097; 50090-6510; 50268-541; 51655-569; 55111-467; 63304-011; 67544-555; 68001-121; 68071-2651; 68071-2930; 68382-567; 70347-200; 71335-0158; 71335-1878; 71335-9706; 71610-161; 71610-642; 0615-7824; 72516-032; 72603-144; 17228-0111; 55111-851; 57451-1147; 60050-003; 75834-293; 16714-854; 24979-040; 50090-3847; 50090-5418; 50090-6260; 50268-542; 50742-618; 51407-403; 51655-519; 51655-919; 53002-1612; 55154-7279; 55700-232; 55700-253; 60687-390; 61919-334; 63187-547; 67544-282; 68001-470; 68382-564; 68382-565; 68788-7206; 68788-8255; 68788-8312; 70518-2868; 70771-1340; 71610-483; 71610-484; 71610-573; 82009-115; 82009-116; 0904-6323; 17228-0109; 17228-1088; 17228-7301; 42419-003; 16714-855; 24979-038; 50090-5053; 50816-100; 51407-404; 51655-888; 53002-2781; 60760-492; 60760-616; 63304-010; 68001-122; 68788-8098; 68788-8327; 69097-408; 70347-100; 70518-3143; 70842-110; 70842-111; 71205-350; 72516-033; 72603-145; 17228-0110; 52932-0713; 53335-0005; 24979-037; 24979-039; 50268-543; 50742-616; 51079-170; 51407-406; 51655-239; 51655-934; 55111-468
UNII TH25PD4CCB
Synonyms Metoprolol | Toprol | Betaloc | Betaloc-Astra | Betaloc Astra | Betalok | CGP-2175 | CGP 2175 | CGP2175 | H 93-26 | H 93 26 | H 9326 | Metoprolol Tartrate | Seloken | Spesicor | Spesikor | Metoprolol Succinate | Metoprolol CR-XL | Metoprolol CR XL | Toprol-XL | Toprol XL | Beloc-Duriles | Beloc Duriles | Lopressor
Chemical Information
Molecular Formula C34H56N2O10
CAS Registry Number 98418-47-4
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Accident12.01.08.001---
Agranulocytosis01.02.03.001---
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Blood alkaline phosphatase13.04.02.010---
Blood lactate dehydrogenase13.04.02.009---
Bradycardia02.03.02.002---
Bronchospasm22.03.01.004; 10.01.03.012--
Catatonia19.11.01.001---
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain08.01.08.002; 02.02.02.011; 22.12.02.003---
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Death08.04.01.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015---
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Hallucination19.10.04.003--
Headache17.14.01.001--
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