Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoclopramide
Drug ID BADD_D01442
Description Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.[L8417] One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]
Indications and Usage For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Marketing Status Prescription; Discontinued
ATC Code A03FA01
DrugBank ID DB01233
KEGG ID D00726
MeSH ID D008787
PubChem ID 4168
TTD Drug ID D08VYV
NDC Product Code 63187-404; 51079-888; 0093-2204; 51662-1367; 0615-8285; 63629-2144; 70518-0669; 42291-596; 60687-620; 55154-8196; 0409-3414; 43353-274; 51662-1288; 70518-1193; 66267-841; 71872-7075; 62559-190; 62559-295; 71872-7076; 68084-676; 60687-631; 71335-0362; 42291-595; 68788-7930; 50090-0132; 55154-4383; 66267-286; 49884-689; 68071-4569; 68788-7226; 0703-4502; 67296-0855; 62559-296; 63187-235; 0615-7698; 71335-0790; 0093-2203; 49999-057; 66267-827; 68071-4326; 51079-886; 50090-2221; 63629-7967; 63629-1961; 63629-8745
Synonyms Metoclopramide | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | Metaclopramide | Maxolon | Rimetin | Metoclopramide Hydrochloride | Hydrochloride, Metoclopramide | Metoclopramide Monohydrochloride | Monohydrochloride, Metoclopramide | Metoclopramide Monohydrochloride, Monohydrate | Primperan | Reglan | Cerucal | Metoclopramide Dihydrochloride | Dihydrochloride, Metoclopramide
Chemical Information
Molecular Formula C14H22ClN3O2
CAS Registry Number 364-62-5
SMILES CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Resting tremor17.01.06.0080.001812%Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.002899%Not Available
Multiple organ dysfunction syndrome08.01.03.057--
Frustration tolerance decreased19.04.02.0160.000725%Not Available
Coeliac disease10.04.04.012; 07.17.01.008; 14.02.01.0070.000725%Not Available
Congenital megaureter20.06.02.001; 03.06.04.0010.001087%Not Available
Dyslalia17.02.08.018; 19.19.03.0090.000725%Not Available
Grunting22.02.01.0300.000725%Not Available
PCO2 decreased13.02.01.0290.000725%Not Available
Post-traumatic stress disorder19.06.06.0020.001087%Not Available
Progressive supranuclear palsy17.03.01.0020.000725%Not Available
Renal dysplasia03.06.01.013; 20.01.06.0130.000725%Not Available
Sciatic nerve injury17.09.02.013; 12.01.01.0040.000725%Not Available
Sciatic nerve palsy17.09.02.0150.001087%Not Available
Urethral valves03.06.02.007; 20.07.04.0020.000284%Not Available
Vesicoureteric reflux20.03.05.0020.000725%Not Available
Adrenal mass05.01.03.0030.000725%Not Available
Respiratory dyskinesia22.02.01.032; 17.01.02.0260.001087%Not Available
General physical condition abnormal13.15.01.0400.002174%Not Available
Deformity08.01.03.0220.032980%Not Available
Multiple system atrophy24.06.03.013; 17.02.10.0230.000189%Not Available
Excessive eye blinking06.05.01.004; 17.17.02.0100.001812%Not Available
Fine motor delay17.01.02.019; 19.22.01.0030.000725%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.001087%Not Available
Quality of life decreased13.18.01.0130.027906%Not Available
Phaeochromocytoma crisis16.24.02.007; 05.01.04.0080.003262%Not Available
Coma scale abnormal13.07.03.0120.000725%Not Available
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