Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methysergide
Drug ID BADD_D01439
Description An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Indications and Usage For the treatment of vascular headache
Marketing Status Discontinued
ATC Code N02CA04
DrugBank ID DB00247
KEGG ID D02357
MeSH ID D008784
PubChem ID 9681
TTD Drug ID D0O6GC
NDC Product Code Not Available
Synonyms Methysergide | Dimethylergometrin | Methylmethylergonovine | UML-491 | UML 491 | UML491 | Sansert | Deseril | Désernil-Sandoz | Désernil Sandoz | Desril | Methysergide Dimaleate | Dimaleate, Methysergide | Methysergide Maleate | Maleate, Methysergide
Chemical Information
Molecular Formula C21H27N3O2
CAS Registry Number 361-37-5
SMILES CCC(CO)NC(=O)C1CN(C2CC3=CN(C4=CC=CC(=C34)C2=C1)C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Aortic embolus24.01.09.002--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Back pain15.03.04.005--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Cardiac murmur13.14.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dissociation19.14.01.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Eosinophilia01.02.04.001--
Euphoric mood19.04.02.006--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.007--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Gravitational oedema08.01.07.005; 02.05.04.014--Not Available
Hyperaesthesia17.02.06.004--Not Available
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