Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methyclothiazide
Drug ID BADD_D01423
Description A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Indications and Usage For use in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Also used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
Marketing Status Prescription; Discontinued
ATC Code C03AA08
DrugBank ID DB00232
KEGG ID D00656
MeSH ID D008736
PubChem ID 4121
TTD Drug ID D03GVC
NDC Product Code 12828-0023
Synonyms Methyclothiazide
Chemical Information
Molecular Formula C9H11Cl2N3O4S2
CAS Registry Number 135-07-9
SMILES CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Asthenia08.01.01.001--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Constipation07.02.02.001--
Cutaneous vasculitis24.05.02.004; 23.06.02.001; 10.02.02.003--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Electrolyte imbalance14.05.01.002--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Glycosuria20.02.01.005--
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypersensitivity10.01.03.003--
Hyperuricaemia14.09.01.003--
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.004--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Leukopenia01.02.02.001--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
The 1th Page    1 2    Next   Last    Total 2 Pages