Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Megestrol acetate
Drug ID BADD_D01372
Description 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Indications and Usage For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Marketing Status Prescription; Discontinued
ATC Code G03AC05; G03DB02; L02AB01
DrugBank ID DB00351
KEGG ID D00952
MeSH ID D019290
PubChem ID 11683
TTD Drug ID Not Available
NDC Product Code 49884-289; 0121-4776; 72969-102; 17856-0907; 49884-290; 0009-5030; 60429-433; 77044-5047; 24979-041; 51927-1670; 49884-230; 68094-361; 63629-7631; 0904-3571; 63739-549; 46439-8722; 0555-0607; 0121-0945; 63629-2221; 64380-158; 49884-907; 71205-943; 55154-5776; 63629-2219; 66689-020; 81646-120; 50383-859; 63629-2220; 60432-126; 51991-313; 0555-0606; 43744-363; 63592-0109; 64380-159; 68094-250; 0904-7072
Synonyms Megestrol Acetate | Acetate, Megestrol | Lin-Megestrol | Lin Megestrol | LinMegestrol | Maygace | Megace | Megostat | Megestat | Megefren | Mestrel | Nu-Megestrol | Nu Megestrol | NuMegestrol | Borea | Apo-Megestrol | Apo Megestrol | ApoMegestrol
Chemical Information
Molecular Formula C24H32O4
CAS Registry Number 595-33-5
SMILES CC1=CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Adrenal insufficiency14.11.01.004; 05.01.02.0010.011834%
Albuminuria20.02.01.001--Not Available
Alopecia23.02.02.001--
Amblyopia06.02.01.001--Not Available
Anaemia01.03.02.001--
Asthenia08.01.01.001--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Cardiac failure02.05.01.001--
Cardiomyopathy02.04.01.001--Not Available
Carpal tunnel syndrome17.09.02.001--Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Cushing's syndrome14.11.01.007; 05.01.01.001; 24.08.04.001; 19.07.03.002--Not Available
Cushingoid24.08.02.004; 19.07.03.001; 14.11.01.006; 05.01.01.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Endometrial cancer21.07.02.002; 16.12.02.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
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