Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Megestrol
Drug ID BADD_D01371
Description 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Indications and Usage For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Marketing Status Not Available
ATC Code G03AC05; G03DB02; L02AB01
DrugBank ID DB00351
KEGG ID D08167
MeSH ID D008535
PubChem ID 19090
TTD Drug ID D04GJN
NDC Product Code 46439-8722; 68094-250; 0555-0607; 17856-0907; 49884-230; 49884-907; 50383-859; 63629-2220; 63739-549; 64380-158; 66689-020; 81646-120; 51991-313; 77044-5047; 0121-4776; 49884-290; 63629-7631; 71205-943; 0009-5030; 24979-041; 60429-433; 63629-2221; 0555-0606; 43744-363; 51927-1670; 63592-0109; 0904-3571; 49884-289; 63629-2219; 0904-7072; 0121-0945; 60432-126; 64380-159; 68094-361; 72969-102; 55154-5776
Synonyms Megestrol | 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione | Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
Chemical Information
Molecular Formula C22H30O3
CAS Registry Number 3562-63-8
SMILES CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Adrenal insufficiency05.01.02.001; 14.11.01.004--
Albuminuria20.02.01.001--Not Available
Alopecia23.02.02.001--
Amblyopia06.02.01.001--Not Available
Anaemia01.03.02.001--
Asthenia08.01.01.001--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Body temperature increased13.15.01.001--Not Available
Cardiac failure02.05.01.001--
Cardiomyopathy02.04.01.001--Not Available
Carpal tunnel syndrome17.09.02.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Cushingoid24.08.02.004; 19.07.03.001; 14.11.01.006; 05.01.01.002--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Embolism venous24.01.01.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Fluid retention14.05.06.002; 20.01.02.003--Not Available
Gastrointestinal pain07.01.05.005--
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
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