Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mecamylamine
Drug ID BADD_D01356
Description A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Indications and Usage For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
Marketing Status Not Available
ATC Code C02BB01
DrugBank ID DB00657
KEGG ID C07511
MeSH ID D008464
PubChem ID 4032
TTD Drug ID D0V8HA
NDC Product Code Not Available
Synonyms Mecamylamine
Chemical Information
Molecular Formula C11H21N
CAS Registry Number 60-40-2
SMILES CC1(C2CCC(C2)C1(C)NC)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Chorea17.01.01.001--Not Available
Constipation07.02.02.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dizziness postural17.02.05.004; 02.01.02.005; 24.06.02.008--Not Available
Fatigue08.01.01.002--
Fibrosis08.03.01.001--Not Available
Glossitis07.14.01.001--Not Available
Ileus07.13.01.001--
Libido decreased21.03.02.005; 19.08.03.001--
Loss of consciousness17.02.04.004--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.001--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Paraesthesia17.02.06.005--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Disturbance in sexual arousal19.08.04.003--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
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