Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Maraviroc
Drug ID BADD_D01352
Description Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Indications and Usage For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.
Marketing Status Prescription
ATC Code J05AX09
DrugBank ID DB04835
KEGG ID D06670
MeSH ID D000077592
PubChem ID 3002977
TTD Drug ID D0NR6S
NDC Product Code 69037-0062; 49702-223; 50923-0414; 12828-0091; 49702-260; 49702-235; 69037-0061; 31722-579; 49702-233; 31722-580; 68554-0040; 49702-237; 76072-1019; 49702-224
Synonyms Maraviroc | 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide | Selzentry | UK-427,857 | UK 427,857 | UK427,857 | UK-427857 | UK 427857 | UK427857
Chemical Information
Molecular Formula C29H41F2N5O
CAS Registry Number 376348-65-1
SMILES CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal neoplasm16.16.02.002; 07.21.04.001--Not Available
Bacterial infection11.02.01.005--Not Available
Pneumonia bacterial22.07.06.004; 11.02.01.009--Not Available
Appetite disorder19.09.01.002; 14.03.01.004--Not Available
Bladder disorder20.03.01.002--Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Endocrine neoplasm malignant16.24.01.005; 05.08.01.006--Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Inflammation08.01.05.007--Not Available
Lung infection22.07.01.008; 11.01.09.008--
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Nail bed infection23.09.04.008; 11.01.12.019--Not Available
Nail infection23.09.04.004; 11.01.12.008--
Nasopharyngeal cancer22.08.02.005; 16.19.05.001--Not Available
Peripheral embolism24.01.02.005--Not Available
Anal cancer16.13.05.001; 07.21.05.001--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Feeling of body temperature change08.01.09.012--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Sebaceous gland disorder23.02.07.004--Not Available
Inner ear disorder04.04.02.002--Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Blood disorder01.05.01.004--Not Available
Autoimmune disorder10.04.04.003--
Bronchitis bacterial22.07.06.005; 11.02.01.011--Not Available
Parasomnia19.02.03.007--Not Available
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