Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Macitentan
Drug ID BADD_D01336
Description Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension.[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity.
Indications and Usage Macitentan is indicated for patients with pulmonary arterial hypertension.
Marketing Status Prescription
ATC Code C02KX04
DrugBank ID DB08932
KEGG ID D10135
MeSH ID C533860
PubChem ID 16004692
TTD Drug ID D0S7JH
NDC Product Code 11722-058; 65015-872; 69766-006; 68225-070; 82245-0117; 69037-0030; 66215-501; 76397-014; 46708-893; 59651-122
Synonyms macitentan | N-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-N'-propylaminosulfonamide | ACT 064992 | ACT064992 | ACT-064992 | Actelion-1 | opsumit
Chemical Information
Molecular Formula C19H20Br2N6O4S
CAS Registry Number 441798-33-0
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood urea increased13.13.01.0060.001732%Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Breast cancer21.05.01.003; 16.10.01.0010.003753%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.023671%
Bronchopulmonary aspergillosis22.07.08.001; 11.03.01.0020.000151%Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Bursitis15.04.01.0010.001443%Not Available
C-reactive protein increased13.09.01.007--Not Available
Carbon dioxide increased13.02.01.0110.000226%Not Available
Cardiac arrest02.03.04.0010.003539%
Cardiac failure02.05.01.0010.009338%
Cardiac failure acute02.05.01.0050.000527%Not Available
Cardiac failure congestive02.05.01.0020.042724%Not Available
Cardiac tamponade02.06.01.001--
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000602%Not Available
Cardiomegaly02.04.02.0010.000678%Not Available
Cardiovascular disorder02.01.01.001; 24.03.02.009--Not Available
Cataract06.06.01.001--
Cellulitis11.02.01.001; 23.09.01.0010.013568%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral thrombosis17.08.01.006; 24.01.04.0030.000577%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.017032%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.038105%Not Available
Chest X-ray abnormal13.19.02.0010.000577%Not Available
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