Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Macitentan
Drug ID BADD_D01336
Description Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension.[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity.
Indications and Usage Macitentan is indicated for patients with pulmonary arterial hypertension.
Marketing Status Prescription
ATC Code C02KX04
DrugBank ID DB08932
KEGG ID D10135
MeSH ID C533860
PubChem ID 16004692
TTD Drug ID D0S7JH
NDC Product Code 11722-058; 65015-872; 69766-006; 68225-070; 82245-0117; 69037-0030; 66215-501; 76397-014; 46708-893; 59651-122
Synonyms macitentan | N-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-N'-propylaminosulfonamide | ACT 064992 | ACT064992 | ACT-064992 | Actelion-1 | opsumit
Chemical Information
Molecular Formula C19H20Br2N6O4S
CAS Registry Number 441798-33-0
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Back disorder15.03.01.0140.002021%Not Available
Back pain15.03.04.0050.023671%
Bacteraemia11.01.11.0010.001155%
Basal cell carcinoma23.08.02.001; 16.03.02.001--Not Available
Biliary colic09.02.01.0010.000577%Not Available
Bilirubin conjugated increased13.03.01.0070.000577%Not Available
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
Blood bilirubin increased13.03.01.0080.010392%
Blood calcium decreased13.11.01.0020.001443%Not Available
Blood cholesterol increased13.12.01.002--
Blood creatinine increased13.13.01.004--
Blood gases abnormal13.02.01.0070.000577%Not Available
Blood glucose abnormal13.02.02.0080.000866%Not Available
Blood glucose decreased13.02.02.0010.002887%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood iron decreased13.11.01.0060.004330%Not Available
Blood lactic acid increased13.02.01.0150.000866%Not Available
Blood magnesium decreased13.11.01.0080.002309%Not Available
Blood potassium abnormal13.11.01.0240.000577%Not Available
Blood potassium decreased13.11.01.0100.007794%Not Available
Blood potassium increased13.11.01.0110.003464%Not Available
Blood pressure abnormal13.14.03.0010.003175%Not Available
Blood pressure decreased13.14.03.0020.006062%Not Available
Blood pressure fluctuation24.06.01.0020.002309%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic decreased13.14.03.0070.000577%Not Available
Blood sodium decreased13.11.01.0120.004619%Not Available
Blood triglycerides increased13.12.03.001--Not Available
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