Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lymecycline
Drug ID BADD_D01333
Description Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.[L13880,L13883] It has been proven a cost-effective alternative to treatment with [minocycline] with comparable safety and efficacy.[A203255] Lymecycline was initially discovered in 1961. It is marketed by Galderma and used in the UK as well as New Zealand in addition to other countries. Lymecycline is not marketed in the USA, however, equivalent drugs are available, such as minocycline and [tetracycline].[A19429,L13880]
Indications and Usage For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease.
Marketing Status Not Available
ATC Code J01AA04
DrugBank ID DB00256
KEGG ID D06884
MeSH ID D008194
PubChem ID 54707177
TTD Drug ID D04VEJ
NDC Product Code Not Available
Synonyms Lymecycline | N-Lysinomethyltetracycline | N Lysinomethyltetracycline | Tetracyclinemethylene Lysine | Lysine, Tetracyclinemethylene | Tetracycline-L-Methylene Lysine | Lysine, Tetracycline-L-Methylene | Tetracycline L Methylene Lysine | Lymecycline Hydrochloride | Hydrochloride, Lymecycline
Chemical Information
Molecular Formula C29H38N4O10
CAS Registry Number 992-21-2
SMILES CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCNCCCCC(C(=O)O)N)N(C )C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Blood bilirubin increased13.03.01.008--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysphagia07.01.06.003--
Enterocolitis07.08.03.003--
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye disorder06.08.03.001--Not Available
Fontanelle bulging18.04.04.001; 17.02.05.006--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Glossitis07.14.01.001--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
Hypersensitivity10.01.03.003--
Immune system disorder10.02.01.001--Not Available
Intracranial pressure increased17.07.02.002--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.004--Not Available
Oesophageal ulcer07.04.05.002--
Oesophagitis07.08.05.001--
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