Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lurasidone
Drug ID BADD_D01330
Description Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Indications and Usage Treatment of schizophrenia.
Marketing Status Prescription
ATC Code N05AE05
DrugBank ID DB08815
KEGG ID D04820
MeSH ID D000069056
PubChem ID 213046
TTD Drug ID D01QGX
NDC Product Code 50370-0036
Synonyms Lurasidone Hydrochloride | Hydrochloride, Lurasidone | Lurasidone HCl | HCl, Lurasidone | SM 13496 | 13496, SM | SM13496 | SM-13,496 | SM 13,496 | SM13,496 | SM-13496 | Lurasidone | N-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl)-1-cyclohexylmethyl)-2,3-bicyclo(2.2.1)heptanedicarboximide | Latuda
Chemical Information
Molecular Formula C28H36N4O2S
CAS Registry Number 367514-87-2
SMILES C1CCC(C(C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)C6C7CCC(C7)C6C5=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.0010.007962%
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.0030.012740%
Weight decreased13.15.01.0050.006370%
Weight increased13.15.01.0060.012740%
White blood cell count decreased13.01.06.012--
White blood cell count increased13.01.06.0130.001592%Not Available
Withdrawal syndrome19.07.02.005; 08.06.02.0120.003185%Not Available
Energy increased08.01.03.0170.001592%Not Available
Homicidal ideation19.05.01.0080.005574%Not Available
Deep vein thrombosis24.01.02.003--Not Available
Lymphatic disorder01.09.01.003--Not Available
Drug tolerance decreased08.06.01.0240.001592%Not Available
Musculoskeletal stiffness15.03.01.0050.004777%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.0010.002389%Not Available
Bipolar disorder19.16.01.0030.007166%Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.001592%
Major depression19.15.01.0030.001592%Not Available
Dyslipidaemia14.08.04.015--Not Available
Angiopathy24.03.02.007--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.001592%
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Electrocardiogram change13.14.05.014--Not Available
Eye movement disorder17.02.05.025; 06.05.02.0080.002389%Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
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