Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loxapine
Drug ID BADD_D01326
Description An antipsychotic agent used in schizophrenia. [PubChem]
Indications and Usage For the management of the manifestations of psychotic disorders such as schizophrenia
Marketing Status Prescription; Discontinued
ATC Code N05AH01
DrugBank ID DB00408
KEGG ID D02340
MeSH ID D008152
PubChem ID 3964
TTD Drug ID D0U5OE
NDC Product Code 0527-1395; 64850-891; 70518-1896; 0527-1397; 35573-438; 0591-0371; 70518-0346; 70518-2120; 0527-1396; 35573-437; 0527-1394; 64850-893; 0591-0372; 0591-0369; 70518-0416; 35573-436; 0591-0370; 64850-890; 64850-892; 70518-1681; 53296-0095; 50090-4701; 70518-0283; 35573-439; 70518-0347
Synonyms Loxapine | 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine | Oxilapine | Cloxazepine | Loxapine Hydrochloride | Hydrochloride, Loxapine | Loxitane | Loxapine Succinate | Succinate, Loxapine | Loxapinsuccinate | Loxipine Succinate | Loxipine Maleate | Maleate, Loxipine | CL-71,563 | CL 71,563 | CL71,563 | Loxapine Monohydrochloride
Chemical Information
Molecular Formula C18H18ClN3O
CAS Registry Number 1977-10-2
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Akinesia17.01.02.003--Not Available
Alopecia23.02.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Asthenia08.01.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort02.02.02.009; 22.02.08.001; 08.01.08.019--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Choreoathetosis17.01.01.003--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.006--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Dystonia17.01.03.001--Not Available
Extrapyramidal disorder17.01.02.007--
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
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