Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorcaserin hydrochloride hemihydrate
Drug ID BADD_D01320
Description Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.
Indications and Usage For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity.
Marketing Status Prescription
ATC Code A08AA11
DrugBank ID DB04871
KEGG ID D11566
MeSH ID C506658
PubChem ID 70678853
TTD Drug ID D01JMC
NDC Product Code 62856-535; 59651-017; 55111-973; 62856-529
Synonyms lorcaserin | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | Belviq | AR-10A | 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine | APD 356 | APD356 | APD-356
Chemical Information
Molecular Formula C22H32Cl4N2O
CAS Registry Number 856681-05-5
SMILES CC1CNCCC2=C1C=C(C=C2)Cl.CC1CNCCC2=C1C=C(C=C2)Cl.O.Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neutrophil count decreased13.01.06.010--
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Rash23.03.13.001--Not Available
Sinus congestion22.04.06.001--Not Available
Stress19.06.02.004--Not Available
Suicidal ideation19.12.01.003--
Toothache07.09.06.001--
Tremor17.01.06.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.004--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Seasonal allergy22.04.04.008; 10.01.04.001; 06.04.01.013--Not Available
Cognitive disorder19.21.02.001; 17.03.03.003--
Inflammation08.01.05.007--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Oropharyngeal pain22.02.05.022; 07.05.05.004--
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