Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loracarbef
Drug ID BADD_D01316
Description Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.
Indications and Usage Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus, S. saprphyticus, S. penumoniae, H. influenzae and M. catarrhalis.
Marketing Status Discontinued
ATC Code J01DC08
DrugBank ID DB00447
KEGG ID D00916
MeSH ID C054920
PubChem ID 5284585
TTD Drug ID D0E9WL
NDC Product Code Not Available
Synonyms loracarbef | KT 3777 | KT-3777 | Lorabid | Lorafem | Lorax | LY 163892 | LY163892 | LY-163892 | Carbac | loracarbef monohydrate
Chemical Information
Molecular Formula C16H16ClN3O4
CAS Registry Number 76470-66-1
SMILES C1CC(=C(N2C1C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thrombocytopenia01.08.01.002--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Urticaria23.04.02.001; 10.01.06.001--
Vaginal infection21.14.02.002; 11.01.10.002--
Vasodilatation24.03.02.003; 23.06.05.006--Not Available
Vomiting07.01.07.003--
Vulvovaginal candidiasis21.14.02.003; 11.03.03.005--Not Available
Haemorrhage24.07.01.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Decreased appetite14.03.01.005; 08.01.09.028--
Renal impairment20.01.03.010--Not Available
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