Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide
Drug ID BADD_D01311
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status Prescription
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09637
MeSH ID C473731
PubChem ID 9853053
TTD Drug ID D0H8VY
NDC Product Code Not Available
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C39H37F6N3O2
CAS Registry Number 182431-12-5
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
TeratogenicityCytochrome P450 3A4P08684T3784826240881
TeratogenicityATP-binding cassette subfamily B member 1AQ9JK64Not Available26240881
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemorrhoidal haemorrhage24.10.02.001; 07.15.03.002--
Pharyngeal lesion22.04.05.011--Not Available
Transaminases increased13.03.01.015--Not Available
Pulmonary mass22.02.07.0040.000121%Not Available
Gastric disorder07.11.01.0030.000241%Not Available
Rectal tenesmus15.05.03.011; 07.03.03.001--Not Available
Vitamin E decreased13.02.05.007--Not Available
Vitamin K decreased13.02.05.008--Not Available
Stomach dilation procedure25.02.03.001--Not Available
Infrequent bowel movements07.02.02.0110.000181%Not Available
Early satiety14.03.01.010; 08.01.09.004; 07.01.06.027--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Hepatic enzyme increased13.03.01.0190.002112%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Inflammation08.01.05.0070.000121%Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Cardiac valve disease02.07.02.0010.000121%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.001388%
Ill-defined disorder08.01.03.0490.000181%Not Available
Inner ear disorder04.04.02.002--Not Available
Blood disorder01.05.01.004--Not Available
Pulmonary function test abnormal13.19.01.005--Not Available
Drug intolerance08.06.01.0130.000543%Not Available
Hepatobiliary disease09.01.08.003--Not Available
Poor quality sleep19.02.05.005; 17.15.04.0020.000121%Not Available
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