ADReCS

Pharmaceutical Information

Drug Name	Lomitapide
Drug ID	BADD_D01311
Description	Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage	Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status	approved; investigational
ATC Code	C10AX12
DrugBank ID	DB08827
KEGG ID	D09637
MeSH ID	C473731
PubChem ID	9853053
TTD Drug ID	D0H8VY
NDC Product Code	Not Available
UNII	82KUB0583F
Synonyms	BMS201038 \| BMS-201038 \| BMS 201038 \| lomitapide \| Juxtapid \| AEGR 733 \| AEGR733 \| AEGR-733

Chemical Information

Molecular Formula	C39H37F6N3O2
CAS Registry Number	182431-12-5
SMILES	C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal discomfort	07.01.06.001	0.002020%		Not Available
Abdominal distension	07.01.04.001	0.001000%
Abdominal pain	07.01.05.002	0.000808%
Abdominal pain lower	07.01.05.010	0.000043%		Not Available
Abdominal pain upper	07.01.05.003	0.002033%
Abdominal tenderness	07.01.05.004	-	-	Not Available
Abnormal faeces	07.01.03.001	0.000084%		Not Available
Alanine aminotransferase increased	13.03.04.005	-	-
Anaemia	01.03.02.001	-	-
Angina pectoris	24.04.04.002; 02.02.02.002	0.000021%
Aortic stenosis	24.04.01.001	0.000021%		Not Available
Arrhythmia	02.03.02.001	0.000054%		Not Available
Arthralgia	15.01.02.001	0.000480%
Arthritis	15.01.01.001	0.000203%
Arthropathy	15.01.01.003	0.000069%		Not Available
Aspartate aminotransferase increased	13.03.04.011	-	-
Asthenia	08.01.01.001	0.000366%		Not Available
Atrial fibrillation	02.03.03.002	0.000064%
Back disorder	15.03.05.003	0.000032%		Not Available
Back pain	15.03.04.005	0.000600%
Blister	23.03.01.001; 12.01.06.002	-	-	Not Available
Blood bilirubin increased	13.03.04.018	-	-
Blood potassium decreased	13.11.01.010	-	-	Not Available
Body temperature increased	13.15.01.001	-	-	Not Available
Bone pain	15.02.01.001	0.000073%
Burning sensation	08.01.09.029; 17.02.06.001	0.000058%		Not Available
Cardiac failure congestive	02.05.01.002	0.000032%		Not Available
Carotene decreased	13.02.05.005	-	-	Not Available
Chest pain	02.02.02.011; 22.12.02.003; 08.01.08.002	0.000606%		Not Available
Chills	15.05.03.016; 08.01.09.001	0.000146%

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