Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide
Drug ID BADD_D01311
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status Prescription
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09637
MeSH ID C473731
PubChem ID 9853053
TTD Drug ID D0H8VY
NDC Product Code Not Available
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C39H37F6N3O2
CAS Registry Number 182431-12-5
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
TeratogenicityATP-binding cassette subfamily B member 1AQ9JK64Not Available26240881
TeratogenicityCytochrome P450 3A4P08684T3784826240881
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.003077%Not Available
Abdominal distension07.01.04.0010.001750%
Abdominal pain07.01.05.0020.001509%
Abdominal pain lower07.01.05.0100.000181%Not Available
Abdominal pain upper07.01.05.0030.003741%
Abdominal tenderness07.01.05.004--Not Available
Abnormal faeces07.01.03.0010.000181%Not Available
Alanine aminotransferase increased13.03.01.0030.000784%
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Arrhythmia02.03.02.0010.000302%Not Available
Arthralgia15.01.02.0010.000845%
Arthritis15.01.01.0010.000483%
Arthropathy15.01.01.0030.000241%Not Available
Aspartate aminotransferase increased13.03.01.0060.000603%
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.000362%
Back disorder15.03.01.0140.000181%Not Available
Back pain15.03.04.0050.001086%
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.01.008--
Blood cholesterol increased13.12.01.0020.002233%
Blood creatine phosphokinase increased13.04.01.0010.000181%
Blood creatinine increased13.13.01.004--
Blood glucose decreased13.02.02.0010.000181%Not Available
Blood glucose increased13.02.02.0020.000483%Not Available
Blood potassium decreased13.11.01.010--Not Available
Blood potassium increased13.11.01.0110.000121%Not Available
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