Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomefloxacin
Drug ID BADD_D01309
Description Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Indications and Usage For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
Marketing Status Discontinued
ATC Code J01MA07; S01AE04
DrugBank ID DB00978
KEGG ID D02318
MeSH ID C053091
PubChem ID 3948
TTD Drug ID D02KOF
NDC Product Code Not Available
Synonyms lomefloxacin | lomenfloxacin | 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | lomefloxacin hydrochloride | Maxaquin | Logiflox | Ocacin | Okacin | Okacyn | SC 4711 | SC-4711 | Décalogiflox | NY 198 | NY-198
Chemical Information
Molecular Formula C17H19F2N3O3
CAS Registry Number 98079-51-7
SMILES CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lacrimation disorder06.08.02.010--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Mania19.16.02.002--
Menopausal symptoms21.02.02.002--Not Available
Menstrual disorder21.01.01.004--Not Available
Mental disability26.01.01.001--Not Available
Mental impairment17.03.03.002; 19.21.02.003--Not Available
Metrorrhagia21.01.01.006--Not Available
Micturition disorder20.02.02.005--Not Available
Monocytosis01.02.01.004--Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.005--Not Available
Myalgia15.05.02.001--
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Nightmare19.02.03.003--Not Available
Nystagmus06.05.02.006; 17.02.02.006--
Oedema14.05.06.010; 08.01.07.006--Not Available
Orchitis21.09.02.002; 11.01.19.004--Not Available
Paraesthesia17.02.06.005--
Paranoia19.05.01.005--Not Available
Pharyngitis07.05.07.004; 22.07.03.004; 11.01.13.003--
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