Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lithium carbonate
Drug ID BADD_D01303
Description Lithium has been used to treat manic episodes since the 19th century[A176642]. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Indications and Usage Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
Marketing Status Prescription; Discontinued
ATC Code N05AN01
DrugBank ID DB14509
KEGG ID D00801
MeSH ID D016651
PubChem ID 11125
TTD Drug ID D04UUH
NDC Product Code 72789-173; 68462-222; 71610-557; 0220-3128; 0054-2531; 31722-546; 68462-224; 0054-0021; 71335-0120; 64117-256; 50090-1470; 46708-303; 70518-0437; 51079-180; 0054-8527; 0054-8526; 0054-2527; 62559-280; 0054-0020; 50090-2799; 0378-1450; 68084-655; 51079-142; 0378-1300; 68462-221; 0054-4527; 70518-0904; 50090-2959; 46708-304; 68084-640; 71335-1067; 0220-3129; 63629-7730; 66039-947; 58118-0545; 70518-0668; 62332-013; 72789-174; 50090-2754; 73309-248; 63629-1916; 64980-278; 82388-001; 0054-2526; 70518-2312; 63629-8282; 63629-1917; 55154-4920; 68428-481; 62332-014; 62756-430; 0054-8528; 70518-0608; 64980-205; 42291-496; 62332-015; 70518-2345; 68462-220; 50090-3918; 23155-763; 68788-7716; 0220-3131; 63187-304; 70518-1753; 71335-1006; 46708-305; 46708-148; 70518-2086; 62332-148; 31722-544; 63629-7903; 68462-223; 72789-171; 72789-172; 50090-3917; 0615-8302; 70518-2699; 0054-8531; 39345-5104; 43063-901; 70518-1434; 31722-545
Synonyms Lithium Carbonate | Carbonate, Lithium | Dilithium Carbonate | Carbonate, Dilithium | Lithane | Lithium Bicarbonate | Bicarbonate, Lithium | Lithobid | Lithonate | CP-15,467-61 | CP 15,467 61 | CP15,46761 | Micalith | NSC-16895 | NSC 16895 | NSC16895 | Priadel | Quilinorm-retard | Quilinorm retard | Quilinormretard | Eskalith | Lithotabs
Chemical Information
Molecular Formula CLi2O3
CAS Registry Number 554-13-2
SMILES [Li+].[Li+].C(=O)([O-])[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Nephrogenic diabetes insipidusVasopressin V2 receptorP48044Not AvailableNot Available
Renal aplasiaVasopressin V2 receptorP48044Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood creatinine decreased13.13.01.003--Not Available
Blood creatinine increased13.13.01.0040.006950%
Blood prolactin increased13.10.03.0020.000818%Not Available
Blood sodium increased13.11.01.0130.001635%Not Available
Blood thyroid stimulating hormone increased13.10.03.0060.001227%
Blood urea increased13.13.01.0060.002044%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.002862%Not Available
Breast engorgement21.05.05.002; 18.08.02.0010.000818%Not Available
Bundle branch block left02.03.01.0070.001635%Not Available
Bundle branch block right02.03.01.0110.001227%Not Available
C-reactive protein increased13.09.01.0070.000818%Not Available
Cardiac arrest02.03.04.0010.000853%
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.000213%Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000320%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000818%Not Available
Catatonia19.11.01.0010.001227%Not Available
Cerebellar atrophy17.11.01.0080.000818%Not Available
Cerebellar syndrome17.02.02.0020.001635%Not Available
Cerebral atrophy17.11.01.0010.000818%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.002453%Not Available
Choking22.02.05.0010.000818%Not Available
Choreoathetosis17.01.01.0030.001227%Not Available
Clonus17.02.05.0020.000818%Not Available
Cogwheel rigidity17.01.05.001; 15.05.04.006--Not Available
Coma17.02.09.0010.002044%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.001067%Not Available
Confusional state19.13.01.001; 17.02.03.0050.006950%
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