Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lithium carbonate
Drug ID BADD_D01303
Description Lithium has been used to treat manic episodes since the 19th century[A176642]. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Indications and Usage Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
Marketing Status Prescription; Discontinued
ATC Code N05AN01
DrugBank ID DB14509
KEGG ID D00801
MeSH ID D016651
PubChem ID 11125
TTD Drug ID D04UUH
NDC Product Code 72789-173; 68462-222; 71610-557; 0220-3128; 0054-2531; 31722-546; 68462-224; 0054-0021; 71335-0120; 64117-256; 50090-1470; 46708-303; 70518-0437; 51079-180; 0054-8527; 0054-8526; 0054-2527; 62559-280; 0054-0020; 50090-2799; 0378-1450; 68084-655; 51079-142; 0378-1300; 68462-221; 0054-4527; 70518-0904; 50090-2959; 46708-304; 68084-640; 71335-1067; 0220-3129; 63629-7730; 66039-947; 58118-0545; 70518-0668; 62332-013; 72789-174; 50090-2754; 73309-248; 63629-1916; 64980-278; 82388-001; 0054-2526; 70518-2312; 63629-8282; 63629-1917; 55154-4920; 68428-481; 62332-014; 62756-430; 0054-8528; 70518-0608; 64980-205; 42291-496; 62332-015; 70518-2345; 68462-220; 50090-3918; 23155-763; 68788-7716; 0220-3131; 63187-304; 70518-1753; 71335-1006; 46708-305; 46708-148; 70518-2086; 62332-148; 31722-544; 63629-7903; 68462-223; 72789-171; 72789-172; 50090-3917; 0615-8302; 70518-2699; 0054-8531; 39345-5104; 43063-901; 70518-1434; 31722-545
Synonyms Lithium Carbonate | Carbonate, Lithium | Dilithium Carbonate | Carbonate, Dilithium | Lithane | Lithium Bicarbonate | Bicarbonate, Lithium | Lithobid | Lithonate | CP-15,467-61 | CP 15,467 61 | CP15,46761 | Micalith | NSC-16895 | NSC 16895 | NSC16895 | Priadel | Quilinorm-retard | Quilinorm retard | Quilinormretard | Eskalith | Lithotabs
Chemical Information
Molecular Formula CLi2O3
CAS Registry Number 554-13-2
SMILES [Li+].[Li+].C(=O)([O-])[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Nephrogenic diabetes insipidusVasopressin V2 receptorP48044Not AvailableNot Available
Renal aplasiaVasopressin V2 receptorP48044Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.0020.003271%
Abnormal weight gain14.03.02.010--Not Available
Acne23.02.01.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000320%
Affective disorder19.04.04.0010.000818%Not Available
Aggression19.05.01.0010.001227%Not Available
Agitation19.06.02.001; 17.02.05.0120.005315%
Akathisia19.06.02.006; 17.01.02.0020.001227%
Albuminuria20.02.01.001--Not Available
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.002044%Not Available
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anaesthesia17.02.07.002--Not Available
Anger19.04.02.0010.001635%Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Apathy19.04.04.0020.000818%Not Available
Aphasia19.21.01.001; 17.02.03.0010.001635%
Arrhythmia02.03.02.0010.001227%Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.001227%Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.004497%Not Available
Ataxia17.02.02.001; 08.01.02.0040.005724%
Atrial fibrillation02.03.03.002--
Atrial tachycardia02.03.03.0040.000818%
Atrioventricular block02.03.01.0020.001227%Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
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