Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Lisinopril
Drug ID BADD_D01300
Description Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs.[A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.[A184844] Lisinopril was granted FDA approval on 29 December 1987.[L8384]
Indications and Usage Lisinopril is indicated for the treatment of acute myocardial infarction, hypertension in patients ≥6 years, and as an adjunct therapy for heart failure.[L8384,L8387] A combination product with hydrochlorothiazide is indicated for the treatment of hypertension.[L8390]
Marketing Status approved; investigational
ATC Code C09AA03
DrugBank ID DB00722
KEGG ID D00362; D08131
MeSH ID D017706
PubChem ID 5362119
TTD Drug ID D07HGR
NDC Product Code 64220-154; 65862-037; 16571-797; 16571-798; 42708-031; 42708-033; 43353-270; 43353-271; 43547-417; 50090-2228; 50090-4678; 51655-707; 53002-1225; 55154-2128; 60687-325; 60760-359; 61919-246; 62135-641; 63187-099; 63629-8823; 65862-039; 65862-040; 65862-042; 68001-336; 68071-5143; 68084-196; 68645-551; 68645-587; 68645-613; 70518-0117; 70518-2600; 71335-0176; 71335-1380; 71610-612; 0615-8254; 76282-419; 76282-729; 0591-0405; 0591-0409; 0904-6797; 0904-7200; 57297-511; 63827-1012; 16729-376; 16729-379; 43353-113; 43353-993; 43547-351; 43547-355; 50090-3763; 51655-146; 55154-8096; 55289-884; 60687-333; 61919-746; 62135-642; 63187-237; 63187-442; 65862-038; 68001-334; 68071-3220; 68180-982; 68645-608; 68645-610; 68788-6407; 70518-1790; 70518-1906; 0591-0406; 71335-0354; 71610-588; 0615-8253; 72865-208; 72865-209; 76282-422; 76282-731; 76282-733; 82009-063; 65862-041; 65977-0009; 23155-714; 31722-172; 42708-142; 43353-301; 50090-3765; 50090-3774; 50090-4725; 50090-4885; 50436-0352; 50436-0354; 51655-399; 51655-729; 51655-999; 58118-1980; 60687-678; 60760-380; 62135-644; 63187-775; 63629-5247; 67296-1202; 67296-1839; 68180-517; 68180-981; 68645-550; 68645-555; 69117-0037; 70882-104; 71205-471; 71335-1295; 71610-624; 0615-8255; 61919-909; 62135-645; 63187-257; 63187-821; 63629-8736; 68001-335; 68180-513; 68645-593; 68788-7012; 68788-7334; 69117-0036; 70518-0544; 70882-103; 70934-155; 71205-180; 71205-742; 71335-0015; 71610-638; 0615-8405; 72865-210; 82009-065; 82982-066; 14593-944; 17404-0011; 16571-794; 16571-795; 42708-154; 43547-418; 43547-419; 50090-0808; 52427-441; 58118-1981; 60760-360; 61919-721; 62135-643; 63187-534; 63629-1761; 67296-1452; 68001-337; 68071-3123; 68645-552; 68645-553; 68645-609; 68788-6820; 68788-6920; 69117-0038; 69117-1003; 70518-1152; 70882-110; 70934-338; 70934-522; 70934-919; 71205-071; 76282-728; 76282-730; 82009-066; 0591-0885; 16571-796; 16729-377; 43063-480; 43063-810; 43063-812; 43547-353; 51655-486; 52427-438; 53002-1123; 60687-646; 60687-667; 63187-825; 68001-332; 68001-486; 68071-3409; 68071-5190; 68180-512; 68180-979; 68180-980; 68645-554; 68645-611; 68788-8351; 70518-0468; 70934-171; 71205-626; 0615-8252; 0904-6800; 67651-0225; 31722-179; 31722-180; 42708-176; 43063-769; 43547-352; 43547-354; 43547-356; 50090-2989; 50090-3175; 51655-995; 52652-3001; 53002-1178; 53002-1463; 60760-358; 60760-390; 60760-438; 61919-717; 61919-736; 63187-098; 63187-780; 68001-333; 68071-2224; 68071-3411; 68084-765; 70518-2561; 70518-2655; 0591-0407; 72789-093; 72789-101; 72865-211; 76282-420; 76282-421; 82009-064; 64220-142; 16729-380; 23155-710; 23155-711; 23155-712; 43063-786; 43063-800; 43063-811; 43063-813; 43353-297; 43353-643; 43353-662; 43353-793; 43547-415; 50090-6303; 51655-335; 51655-411; 52427-442; 62135-640; 63187-722; 68071-3064; 68788-8310; 69117-1001; 71335-0075; 71610-312; 71610-406; 71610-536; 72865-212; 76282-418; 0904-6798; 0904-6799; 65730-1301; 42708-096; 42708-165; 50090-2431; 50090-4887; 52427-443; 55154-4992; 55154-8078; 55700-480; 60760-357; 60760-455; 68645-532; 70518-1156; 70518-1316; 70518-3166; 0591-0408; 76282-417; 16571-799; 16729-375; 31722-176; 31722-178; 42708-032; 43063-074; 43353-009; 43353-298; 43547-414; 43547-416; 50090-5120; 50436-0353; 51655-994; 52427-440; 53002-2123; 55154-2329; 55700-479; 55700-547; 60687-656; 67296-1154; 68645-612; 68788-7666; 69117-1002; 71335-0498; 71335-0536; 72865-213; 76282-732; 82009-062; 16729-378; 23155-713; 23155-715; 31722-177; 42708-094; 43063-814; 43063-815; 52427-439
UNII E7199S1YWR
Synonyms Lisinopril | Lysinopril | Lisinopril Sulfate (1:2) | Prinivil | Zestril | Lisinopril Maleate (1:1) | MK-521
Chemical Information
Molecular Formula C21H31N3O5
CAS Registry Number 76547-98-3
SMILES C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rosacea23.02.08.0010.000005%Not Available
Salivary hypersecretion07.06.01.009--Not Available
Screaming19.04.02.020; 08.01.03.0990.000005%Not Available
Shock24.06.02.002--Not Available
Sinus congestion22.04.06.0010.000018%Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Skin fissures23.03.03.0080.000010%Not Available
Skin infection11.01.12.003; 23.11.04.007--
Skin lesion23.03.03.010--Not Available
Skin necrosis23.03.03.0110.000005%Not Available
Skin odour abnormal23.03.03.0120.000010%
Sleep apnoea syndrome19.02.05.002; 17.15.05.001; 22.02.01.0130.000018%
Sleep disorder19.02.04.001--Not Available
Somnambulism19.02.03.006; 17.15.02.0040.000005%Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.0030.000105%Not Available
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Stillbirth18.01.02.002; 08.04.01.006--Not Available
Stomatitis07.05.06.005--
Stridor22.04.02.0030.000040%
Swelling08.01.03.0150.000229%Not Available
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.0180.000398%Not Available
Swollen tongue10.01.05.015; 07.14.02.003; 23.04.01.0140.000650%Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.0080.000098%
Tachycardia02.03.02.007--Not Available
Tendon disorder12.01.07.019; 15.07.01.002--Not Available
Tension19.06.02.005--Not Available
Therapeutic response decreased08.06.01.016--Not Available
Throat irritation22.12.03.029; 07.05.05.0370.000066%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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