Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Liraglutide
Drug ID BADD_D01298
Description Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist[Label,A6932]. Liraglutide is 97% homologous to native human GLP-1 by substituting arginine for lysine at position 34[A6932]. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide precursor[A6932]. Liraglutide was granted FDA approval on Januray 25, 2010[L6070].
Indications and Usage For use in/treatment of diabetes mellitus type 2.
Marketing Status Prescription
ATC Code A10BJ02
DrugBank ID DB06655
KEGG ID D06404
MeSH ID D000069450
PubChem ID 16134956
TTD Drug ID D03GOI
NDC Product Code 66558-0193; 69766-034; 0169-4060; 71796-022; 73569-007; 32861-0003; 50090-4503; 52221-122; 65129-1375; 50090-4257; 70155-003; 50090-2853; 41524-0011; 14403-0009; 76177-118; 0169-2800; 66558-0181; 0420-9006
Synonyms Liraglutide | Victoza | Saxenda | NN 2211 | 2211, NN | NN2211 | NN-2211
Chemical Information
Molecular Formula C172H265N43O51
CAS Registry Number 204656-20-2
SMILES CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O) NC(C(C)CC)C(=O)NC(C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O )NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O )C(CCC(=O)N)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O )C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C( CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC6=CN=CN6) N)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oropharyngeal swelling10.01.05.014; 07.05.04.002; 23.04.01.013; 22.04.05.005--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.002--Not Available
Pancreatitis haemorrhagic07.18.01.003--Not Available
Pancreatitis necrotising07.18.01.004--Not Available
Papillary thyroid cancer16.24.03.002; 05.02.05.005--Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.016--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Suicidal ideation19.12.01.003--
Swelling face23.04.01.018; 10.01.05.018--Not Available
Tachycardia02.03.02.007--Not Available
Toothache07.09.06.001--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Colon adenoma16.05.02.005; 07.20.01.007--Not Available
Type IV hypersensitivity reaction10.01.03.022--Not Available
Lipase abnormal13.05.01.005--Not Available
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