Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levonorgestrel
Drug ID BADD_D01281
Description Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available.[L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Indications and Usage For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
Marketing Status Prescription; OTC; Discontinued
ATC Code G03AC03; G03AD01
DrugBank ID DB00367
KEGG ID D00950
MeSH ID D016912
PubChem ID 13109
TTD Drug ID D0BA9U
NDC Product Code 50419-424; 73302-911; 22552-0047; 43386-622; 45541-1244; 51660-723; 12866-1010; 50419-422; 63190-0660; 63190-0130; 45541-1174; 65129-2003; 50090-1141; 62756-720; 58602-721; 16714-809; 50419-423; 66499-0018; 69536-162; 69536-146; 40032-622; 71205-361; 57297-852; 0113-2003; 65089-0036; 68071-4247; 58602-712; 0536-1142; 68071-4294; 64122-605; 44132-004; 50090-3830; 68180-853; 69536-200; 51508-012; 69536-103; 58602-841; 59057-002; 53104-7669; 62756-718; 62756-723; 69953-515; 68180-852; 70700-164; 69536-133; 71205-120; 59057-001; 50102-211; 0023-5858; 69953-616; 63190-0850; 68071-4126; 44132-012
Synonyms Levonorgestrel | l-Norgestrel | l Norgestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)- | D-Norgestrel | D Norgestrel | Microval | duofem | Microlut | Mirena | Norgeston | Norplant-2 | Norplant 2 | Norplant2 | NorLevo | Norplant | Plan B | Vikela | Cerazet | Capronor
Chemical Information
Molecular Formula C21H28O2
CAS Registry Number 797-63-7
SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Endometrial hypertrophy21.07.01.0030.010423%Not Available
Endometriosis21.07.01.0040.067747%Not Available
Endometritis21.14.01.002; 11.01.10.0050.022930%Not Available
Epilepsy17.12.03.002--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Erythema nodosum23.07.02.001; 10.02.01.0200.004169%Not Available
Essential thrombocythaemia16.21.03.004; 01.13.03.0030.002085%Not Available
Extrasystoles02.03.02.0030.009380%Not Available
Eye disorder06.08.03.001--Not Available
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.0020.029183%
Eye swelling06.08.03.003--Not Available
Face oedema10.01.05.002; 23.04.01.004; 08.01.07.003--
Facial pain08.01.08.012--
Facial paralysis17.04.03.0080.013549%Not Available
Fatigue08.01.01.002--
Fear19.06.03.0010.124028%Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.008--Not Available
Feeling hot08.01.09.009--Not Available
Feeling jittery08.01.09.016--Not Available
Feeling of despair19.15.02.0060.003127%Not Available
Female orgasmic disorder21.03.02.018; 19.08.01.0050.003127%Not Available
Fibrin D dimer increased13.01.02.0360.003127%Not Available
Fibroadenoma of breast21.05.01.005; 16.14.01.0010.004169%Not Available
Fibrocystic breast disease16.14.01.003; 21.05.01.0020.008338%Not Available
Fibroma16.02.02.010; 15.09.01.0040.008338%Not Available
Fibrosis08.03.01.0010.002085%Not Available
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