Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levocabastine hydrochloride
Drug ID BADD_D01270
Description Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979.
Indications and Usage As an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis.
Marketing Status Discontinued
ATC Code R01AC02; S01GX02
DrugBank ID DB01106
KEGG ID D01717
MeSH ID C047340
PubChem ID 54384
TTD Drug ID D08SEI
NDC Product Code 65089-0042
Synonyms levocabastine | 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-4-piperidinecarboxylic acid | livostin | livocab | levophta | levocabastine hydrochloride | lévophta | Bilina
Chemical Information
Molecular Formula C26H30ClFN2O2
CAS Registry Number 79547-78-7
SMILES CC1CN(CCC1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Eye discharge06.04.05.001--Not Available
Eye pain06.08.03.002--
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Fatigue08.01.01.002--
Headache17.14.01.001--
Lacrimation increased06.08.02.004--
Nausea07.01.07.001--
Ocular hyperaemia06.04.05.004--Not Available
Pain08.01.08.004--
Pharyngitis11.01.13.003; 07.05.07.004; 22.07.03.004--
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Visual impairment06.02.06.008--Not Available
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