Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levetiracetam
Drug ID BADD_D01265
Description Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no potential to produce, or be subject to, pharmacokinetic interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.[A185927]
Indications and Usage Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AX14
DrugBank ID DB01202
KEGG ID D00709
MeSH ID D000077287
PubChem ID 5284583
TTD Drug ID D0E1XL
NDC Product Code 76282-247; 65162-538; 28877-5960; 50474-001; 68180-113; 63739-411; 69367-333; 51991-651; 68001-114; 70518-1921; 51927-0107; 42385-957; 0409-1886; 60505-3517; 16714-034; 70518-1796; 63629-8315; 55111-870; 60687-249; 24689-106; 51552-1448; 50474-597; 47335-576; 16714-358; 55154-7887; 50474-596; 55154-5782; 43485-104; 72865-188; 69102-106; 0121-0799; 63629-4675; 51672-4136; 63323-400; 65841-703; 0378-5617; 0904-6051; 68001-117; 66689-028; 68084-859; 13668-017; 43547-346; 14789-110; 0378-5613; 55111-182; 25021-780; 12666-0014; 68382-168; 52343-071; 16714-355; 35208-031; 13668-016; 16571-788; 43547-221; 31722-574; 68180-112; 65862-245; 54838-548; 63629-4137; 42185-7039; 10370-195; 10370-214; 0121-2397; 61919-559; 0409-2011; 16571-787; 68180-114; 43547-223; 66689-029; 43063-499; 76494-530; 66174-0044; 47133-574; 52343-072; 72789-152; 75834-246; 52038-171; 60505-3518; 80705-101; 76282-246; 76494-529; 71930-063; 51927-0088; 68083-153; 71052-043; 69076-500; 38779-2900; 68001-402; 44567-501; 50090-4023; 70860-602; 16714-357; 64980-365; 65862-247; 62331-010; 0904-7060; 68084-882; 51672-4141; 50474-599; 68083-152; 47335-573; 68554-0065; 68001-115; 67457-790; 68084-870; 55154-5699; 0615-7978; 0121-4799; 71093-144; 43485-102; 64980-363; 65162-529; 0378-5615; 65162-528; 16729-065; 70518-2320; 63187-360; 43485-103; 69102-107; 0904-7124; 50228-190; 0904-6052; 72189-190; 50090-3518; 71930-065; 68001-405; 0143-9574; 16571-789; 67296-1248; 70518-0947; 55111-183; 63739-787; 36998-0117; 68180-117; 65862-261; 55154-3367; 71335-0139; 64980-362; 16714-310; 17856-0574; 68084-893; 72865-189; 0904-7123; 60432-831; 43547-222; 60429-349; 50228-189; 68071-4508; 68180-118; 0395-8160; 50268-470; 71930-062; 50090-2456; 36998-5980; 69339-157; 64220-192; 68788-7074; 13668-014; 72485-106; 69367-332; 35208-032; 55111-248; 61919-068; 65372-1148; 16714-035; 36998-5950; 28877-5970; 69076-750; 70518-1969; 51672-4142; 68083-154; 52343-069; 52343-070; 50474-598; 65862-315; 51672-4137; 61919-552; 36998-5960; 51927-0155; 72643-025; 71901-605; 16571-790; 81414-001; 44567-502; 71205-880; 65841-704; 68382-165; 66689-030; 0904-7125; 68001-404; 70166-081; 51927-4721; 63629-7516; 58032-0132; 55154-7647; 13668-015; 43063-617; 50383-241; 69102-108; 67296-1636; 51079-821; 50090-2875; 16714-356; 36998-5970; 65862-246; 0472-0235; 43489-122; 69102-105; 81646-116; 62756-880; 50090-3264; 50228-472; 71335-0748; 71335-0048; 0121-1598; 75834-245; 68001-118; 14789-330; 71930-064; 61919-685; 14789-220; 50090-3889; 81665-100; 50474-594; 68001-113; 16714-354; 16729-067; 57572-0034; 63739-019; 55150-177; 42385-955; 65162-685; 58118-1112; 68788-7430; 42385-956; 76282-248; 70518-2810; 50228-473; 50090-1333; 67835-0006; 71335-0702; 70518-3317; 31722-539; 68180-115; 67457-266; 31722-538; 71335-0694; 64220-152; 66689-102; 43547-224; 47133-575; 36998-5990; 64376-697; 50474-002; 16729-064; 39822-4000; 76494-531; 70860-604; 62512-0030; 43547-345; 42385-954; 72640-004; 0615-7979; 80705-100; 51672-4143; 70860-603; 76494-528; 50090-5495; 44567-500; 50090-5760; 67457-265; 65162-539; 64980-364; 68001-116; 43489-124; 72969-039; 16729-066; 68788-7884; 72865-187; 68180-099; 72189-229; 70518-2230; 0615-7976; 0378-5619; 36998-5940; 31722-536; 43485-101; 68788-7534; 55111-181; 72865-190; 51224-013; 42571-331; 70518-1998; 60429-350; 0904-6053; 67457-255; 63629-2073; 70518-2328; 65862-250; 50474-595; 50683-0322; 60505-3280; 70518-1901; 62350-0059; 0143-9673; 31722-537; 68001-403; 71205-881; 70518-3192; 44567-503; 55289-097; 28877-5950; 63739-795; 68225-021; 0615-7977; 16714-537
Synonyms Levetiracetam | Etiracetam, S-isomer | Etiracetam, S isomer | S-isomer Etiracetam | Ucb L059 | Ucb-L059 | UCB 6474 | UCB-6474 | UCB6474 | Etiracetam, R-isomer | Etiracetam, R isomer | R-isomer Etiracetam | Etiracetam, (R)- | Keppra | Etiracetam | alpha-ethyl-2-oxo-1-Pyrrolidineacetamide | alpha ethyl 2 oxo 1 Pyrrolidineacetamide | Ucb L060 | Ucb-L060 | UcbL060
Chemical Information
Molecular Formula C8H14N2O2
CAS Registry Number 102767-28-2
SMILES CCC(C(=O)N)N1CCCC1=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Amniotic band syndrome18.05.01.006; 15.11.07.017; 03.11.07.0170.002095%Not Available
Conduct disorder19.21.04.0020.000571%Not Available
Prominent epicanthal folds06.06.04.022; 03.01.07.0030.000149%Not Available
Stress cardiomyopathy02.04.01.012; 24.04.04.026--Not Available
Fear of death19.06.03.0060.000381%Not Available
Periventricular nodular heterotopia17.19.03.010; 03.10.03.0110.000298%Not Available
Asthenospermia21.03.03.0060.000571%Not Available
Naevus flammeus24.03.03.036; 03.05.01.020; 23.05.01.0160.002095%Not Available
Quality of life decreased13.18.01.013--Not Available
Skin plaque23.03.03.0440.000381%Not Available
Foetal hypokinesia18.03.02.0150.000571%Not Available
Coma scale abnormal13.07.03.0120.000381%Not Available
Klebsiella test positive13.08.01.0110.000571%Not Available
Motor developmental delay17.01.02.023; 19.22.01.0050.003047%Not Available
Idiopathic generalised epilepsy17.12.03.0260.002856%Not Available
Seizure cluster17.12.03.0290.001904%Not Available
Hyporesponsive to stimuli17.02.05.0570.000571%Not Available
Encephalitis autoimmune10.04.10.012; 17.06.05.002; 16.32.01.0060.002285%Not Available
Skeletal dysplasia03.11.01.007; 15.11.01.0070.000381%Not Available
Congenital skin dimples23.07.05.006; 03.05.01.0170.001523%Not Available
Preterm premature rupture of membranes18.02.02.0160.000381%Not Available
Craniofacial deformity15.11.02.005; 03.11.02.0050.000149%Not Available
Infantile haemangioma24.03.06.009; 16.02.01.0070.000952%Not Available
Change in seizure presentation17.12.03.0220.000571%Not Available
Disorganised speech19.19.02.005; 17.02.08.0170.000381%Not Available
Infantile apnoea18.04.15.003; 22.11.02.0040.001333%Not Available
Intracranial mass17.11.01.0170.000762%Not Available
Limbic encephalitis10.04.10.013; 17.06.05.004; 16.32.01.0070.000381%Not Available
Selective eating disorder19.09.01.012; 14.03.02.0240.003809%Not Available
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