Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levetiracetam
Drug ID BADD_D01265
Description Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no potential to produce, or be subject to, pharmacokinetic interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.[A185927]
Indications and Usage Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AX14
DrugBank ID DB01202
KEGG ID D00709
MeSH ID D000077287
PubChem ID 5284583
TTD Drug ID D0E1XL
NDC Product Code 76282-247; 65162-538; 28877-5960; 50474-001; 68180-113; 63739-411; 69367-333; 51991-651; 68001-114; 70518-1921; 51927-0107; 42385-957; 0409-1886; 60505-3517; 16714-034; 70518-1796; 63629-8315; 55111-870; 60687-249; 24689-106; 51552-1448; 50474-597; 47335-576; 16714-358; 55154-7887; 50474-596; 55154-5782; 43485-104; 72865-188; 69102-106; 0121-0799; 63629-4675; 51672-4136; 63323-400; 65841-703; 0378-5617; 0904-6051; 68001-117; 66689-028; 68084-859; 13668-017; 43547-346; 14789-110; 0378-5613; 55111-182; 25021-780; 12666-0014; 68382-168; 52343-071; 16714-355; 35208-031; 13668-016; 16571-788; 43547-221; 31722-574; 68180-112; 65862-245; 54838-548; 63629-4137; 42185-7039; 10370-195; 10370-214; 0121-2397; 61919-559; 0409-2011; 16571-787; 68180-114; 43547-223; 66689-029; 43063-499; 76494-530; 66174-0044; 47133-574; 52343-072; 72789-152; 75834-246; 52038-171; 60505-3518; 80705-101; 76282-246; 76494-529; 71930-063; 51927-0088; 68083-153; 71052-043; 69076-500; 38779-2900; 68001-402; 44567-501; 50090-4023; 70860-602; 16714-357; 64980-365; 65862-247; 62331-010; 0904-7060; 68084-882; 51672-4141; 50474-599; 68083-152; 47335-573; 68554-0065; 68001-115; 67457-790; 68084-870; 55154-5699; 0615-7978; 0121-4799; 71093-144; 43485-102; 64980-363; 65162-529; 0378-5615; 65162-528; 16729-065; 70518-2320; 63187-360; 43485-103; 69102-107; 0904-7124; 50228-190; 0904-6052; 72189-190; 50090-3518; 71930-065; 68001-405; 0143-9574; 16571-789; 67296-1248; 70518-0947; 55111-183; 63739-787; 36998-0117; 68180-117; 65862-261; 55154-3367; 71335-0139; 64980-362; 16714-310; 17856-0574; 68084-893; 72865-189; 0904-7123; 60432-831; 43547-222; 60429-349; 50228-189; 68071-4508; 68180-118; 0395-8160; 50268-470; 71930-062; 50090-2456; 36998-5980; 69339-157; 64220-192; 68788-7074; 13668-014; 72485-106; 69367-332; 35208-032; 55111-248; 61919-068; 65372-1148; 16714-035; 36998-5950; 28877-5970; 69076-750; 70518-1969; 51672-4142; 68083-154; 52343-069; 52343-070; 50474-598; 65862-315; 51672-4137; 61919-552; 36998-5960; 51927-0155; 72643-025; 71901-605; 16571-790; 81414-001; 44567-502; 71205-880; 65841-704; 68382-165; 66689-030; 0904-7125; 68001-404; 70166-081; 51927-4721; 63629-7516; 58032-0132; 55154-7647; 13668-015; 43063-617; 50383-241; 69102-108; 67296-1636; 51079-821; 50090-2875; 16714-356; 36998-5970; 65862-246; 0472-0235; 43489-122; 69102-105; 81646-116; 62756-880; 50090-3264; 50228-472; 71335-0748; 71335-0048; 0121-1598; 75834-245; 68001-118; 14789-330; 71930-064; 61919-685; 14789-220; 50090-3889; 81665-100; 50474-594; 68001-113; 16714-354; 16729-067; 57572-0034; 63739-019; 55150-177; 42385-955; 65162-685; 58118-1112; 68788-7430; 42385-956; 76282-248; 70518-2810; 50228-473; 50090-1333; 67835-0006; 71335-0702; 70518-3317; 31722-539; 68180-115; 67457-266; 31722-538; 71335-0694; 64220-152; 66689-102; 43547-224; 47133-575; 36998-5990; 64376-697; 50474-002; 16729-064; 39822-4000; 76494-531; 70860-604; 62512-0030; 43547-345; 42385-954; 72640-004; 0615-7979; 80705-100; 51672-4143; 70860-603; 76494-528; 50090-5495; 44567-500; 50090-5760; 67457-265; 65162-539; 64980-364; 68001-116; 43489-124; 72969-039; 16729-066; 68788-7884; 72865-187; 68180-099; 72189-229; 70518-2230; 0615-7976; 0378-5619; 36998-5940; 31722-536; 43485-101; 68788-7534; 55111-181; 72865-190; 51224-013; 42571-331; 70518-1998; 60429-350; 0904-6053; 67457-255; 63629-2073; 70518-2328; 65862-250; 50474-595; 50683-0322; 60505-3280; 70518-1901; 62350-0059; 0143-9673; 31722-537; 68001-403; 71205-881; 70518-3192; 44567-503; 55289-097; 28877-5950; 63739-795; 68225-021; 0615-7977; 16714-537
Synonyms Levetiracetam | Etiracetam, S-isomer | Etiracetam, S isomer | S-isomer Etiracetam | Ucb L059 | Ucb-L059 | UCB 6474 | UCB-6474 | UCB6474 | Etiracetam, R-isomer | Etiracetam, R isomer | R-isomer Etiracetam | Etiracetam, (R)- | Keppra | Etiracetam | alpha-ethyl-2-oxo-1-Pyrrolidineacetamide | alpha ethyl 2 oxo 1 Pyrrolidineacetamide | Ucb L060 | Ucb-L060 | UcbL060
Chemical Information
Molecular Formula C8H14N2O2
CAS Registry Number 102767-28-2
SMILES CCC(C(=O)N)N1CCCC1=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Astrocytoma17.20.01.002; 16.30.01.0020.000099%Not Available
Ataxia17.02.02.001; 08.01.02.0040.004189%
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.002--
Atrial septal defect03.07.02.002; 02.04.02.0090.012759%Not Available
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block first degree02.03.01.0040.001523%
Atrioventricular block second degree02.03.01.0050.000762%
Attention deficit/hyperactivity disorder19.21.04.0010.001333%Not Available
Aura17.02.07.0110.003237%Not Available
Autism19.22.02.001; 17.03.05.0010.001714%Not Available
Azoospermia21.03.03.0010.000381%
Back pain15.03.04.005--
Blepharospasm17.17.02.001; 06.05.01.0010.001904%Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Blindness transient17.17.01.004; 06.02.02.0020.000381%Not Available
Blindness unilateral17.17.01.016; 06.02.02.0090.000381%Not Available
Blister23.03.01.001; 12.01.06.0020.003618%Not Available
Blood albumin decreased13.09.01.0010.000571%Not Available
Blood bilirubin increased13.03.01.008--
Blood creatine phosphokinase increased13.04.01.0010.005903%
Blood creatine phosphokinase MB increased13.04.01.0060.001333%Not Available
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.001333%
Blood magnesium decreased13.11.01.0080.000381%Not Available
Blood osmolarity decreased13.11.02.0050.000762%Not Available
Blood potassium decreased13.11.01.010--Not Available
The 3th Page    First    Pre   3 4 5 6 7    Next   Last    Total 35 Pages