Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Latanoprost
Drug ID BADD_D01251
Description Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment.[A184493] It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as [Timolol]. Another benefit latanoprost is that it can be administered once a day.[A184490]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Marketing Status Prescription; Discontinued
ATC Code S01EE01
DrugBank ID DB00654
KEGG ID D00356
MeSH ID D000077338
PubChem ID 5311221
TTD Drug ID D0C6NM
NDC Product Code 90027-006; 68071-2376; 59762-0333; 47335-317; 24208-463; 63190-0710; 65326-004; 45542-1156; 0009-5172; 51927-4864; 42385-039; 55545-0462; 71684-0547; 45542-1159; 68071-4893; 12079-0475; 64980-516; 50090-1920; 61314-547; 51927-0091; 68245-0002; 71205-154; 65035-128; 51552-1385; 17478-625; 46144-156; 65862-872; 40016-001; 71052-041; 61919-112; 65727-026; 61556-050; 65427-007; 81997-001; 68071-4650; 51927-0090; 24002-0018; 54893-0010; 10695-048; 0013-8303; 82231-111; 68071-4612; 70069-421
Synonyms Latanoprost | PhXA34 | PHXA41 | Xalatan
Chemical Information
Molecular Formula C26H40O5
CAS Registry Number 130209-82-4
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypotension24.06.03.002--
Hypotony of eye06.08.03.0040.000225%Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.0010.000788%Not Available
Influenza like illness08.01.03.010--
Injury corneal12.01.04.018; 06.11.03.0020.000450%Not Available
Insomnia19.02.01.002; 17.15.03.0020.001463%
Intraocular pressure increased13.07.04.0020.009681%Not Available
Iritis10.02.01.022; 06.04.03.0020.000338%Not Available
Keratitis06.04.02.0020.000788%
Keratoconus06.06.03.0170.000225%Not Available
Keratopathy06.06.03.0070.000225%Not Available
Lacrimation increased06.08.02.0040.002476%
Leukopenia01.02.02.001--Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.000338%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.000225%Not Available
Macular degeneration06.09.03.0010.000563%Not Available
Macular oedema06.04.06.0050.000563%Not Available
Malaise08.01.01.0030.002589%
Malignant melanoma23.08.01.001; 16.03.01.0010.000225%Not Available
Memory impairment19.20.01.003; 17.03.02.003--
Migraine24.03.05.003; 17.14.02.001--Not Available
Muscle spasms15.05.03.004--
Muscular weakness15.05.06.001; 17.05.03.0050.000563%
Myalgia15.05.02.0010.000901%
Mydriasis17.02.11.003; 06.05.03.0040.000338%Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.0010.000563%
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
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