Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lanreotide acetate
Drug ID BADD_D01244
Description Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured by the company, _Ipsen Pharmaceuticals_ as lanreotide acetate, and marketed as _Somatuline_. It is approved in several countries worldwide, including the United Kingdom, Australia, and Canada. Lanreotide was first approved for use in the United States by the FDA on August 30, 2007.
Indications and Usage Lanreotide is a somatostatin analog approved for treatment of neuroendocrine tumours and acromegaly. (2)
Marketing Status Prescription
ATC Code H01CB03
DrugBank ID DB06791
KEGG ID D04666
MeSH ID C060347
PubChem ID 71349
TTD Drug ID D0M2YE
NDC Product Code 32861-0006; 71161-114; 15054-1120; 69097-890; 71161-116; 52076-6264; 35207-0011; 71161-115; 15054-1090; 69097-870; 69097-880; 52076-6272; 15054-1060
Synonyms lanreotide | 3-(2-naphthyl)alanyl-cystinyl-tyrosyl-tryptophyl-lysyl-valyl-cystinyl-threonine amide | D-Nal-Cys-Tyr-Trp-Lys-Val-Cys-Thr-NH2 | angiopeptin | naphthalenyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)threoninamide | L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide | Nal-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)-Thr-NH2 | Nal-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2 | 2-naphthylalanyl-cyclo(cysteinyl-tyrosyl-tryptophyl-lysyl-valyl-cysteinyl)-threoninamide | 3-(2-naphthyl)-D-Ala-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 | naphthyl-cyclo(Cys-Tyr-Trp-Lys-Val-Cys)Thr-NH2 | BIM 23014 | BIM-23014 | DC 13-116 | DC13-116 | DC-13-116 | lanreotide acetate | Somatulina | Somatuline | lanreotide-SR | BIM 23014 C | BIM 23014C | BIM-23014 C | 188Re-lanreotide | Somatulin
Chemical Information
Molecular Formula C54H69N11O10S2
CAS Registry Number 108736-35-2
SMILES CC(C)C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC 4=CC=C(C=C4)O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)N)C(=O)NC(C(C)O)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Peripheral ischaemia24.04.03.002--
Pruritus23.03.12.001--
Renal pain20.02.03.003--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Sinus bradycardia02.03.03.009--
Steatorrhoea07.17.01.002--Not Available
Tension19.06.02.005--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Ventricular arrhythmia02.03.04.006--
Vertigo17.02.12.002; 04.04.01.003--
Visual impairment06.02.06.008--Not Available
Vitamin B12 deficiency14.12.02.004--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Nodule08.03.05.002--Not Available
Injection site nodule23.07.04.009; 12.07.03.034; 08.02.03.034--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Induration08.01.03.020--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Inflammation08.01.05.007--Not Available
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
The 4th Page    First    Pre   4 5    Next   Last    Total 5 Pages