Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamivudine
Drug ID BADD_D01242
Description A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Indications and Usage For the treatment of HIV infection and chronic hepatitis B (HBV).
Marketing Status Prescription
ATC Code J05AF05
DrugBank ID DB00709
KEGG ID D00353
MeSH ID D019259
PubChem ID 60825
TTD Drug ID D07TQV
NDC Product Code 60505-3250; 53873-075; 53873-073; 55773-0589; 49702-204; 49702-203; 50742-623; 65015-701; 68180-603; 50742-624; 65862-259; 53873-074; 54838-566; 31722-752; 64380-711; 49702-205; 31722-001; 70159-001; 52482-003; 64380-710; 31722-753; 68554-0043; 65862-026; 33342-001; 69097-167; 70518-3267; 57237-274; 65015-756; 70518-2067; 70518-2070; 67835-0017; 0173-0662; 53104-7538; 60687-362; 0173-0663; 60505-3252; 53104-7677; 65862-025; 68180-602; 65862-055; 68554-0016; 66993-478; 31722-754; 65862-577; 69097-166; 42385-714; 33342-002; 60505-3251; 60429-354; 60429-353; 0904-6583
Synonyms Lamivudine | 3TC | 2',3'-Dideoxy-3'-thiacytidine | 2',3' Dideoxy 3' thiacytidine | Epivir | Lamivudine, (2S-cis)-Isomer | BCH-189 | BCH 189 | BCH189 | GR-109714X | GR109714X
Chemical Information
Molecular Formula C8H11N3O3S
CAS Registry Number 134678-17-4
SMILES C1C(OC(S1)CO)N2C=CC(=NC2=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arthralgia15.01.02.001--
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.006957%
Aspartate aminotransferase13.03.01.032--Not Available
Aspartate aminotransferase increased13.03.01.0060.016233%
Asthenia08.01.01.0010.039422%Not Available
Ataxia17.02.02.001; 08.01.02.0040.004638%
Atrial septal defect03.07.02.002; 02.04.02.0090.001815%Not Available
Auricular swelling04.01.01.002--Not Available
Back pain15.03.04.005--
Basedow's disease06.09.04.003; 05.02.02.003; 10.04.08.004--Not Available
Blood bilirubin13.03.01.040--Not Available
Blood bilirubin increased13.03.01.0080.020870%
Blood creatine phosphokinase increased13.04.01.0010.013914%
Blood creatinine increased13.13.01.004--
Blood pressure increased13.14.03.005--Not Available
Blood triglycerides increased13.12.03.001--Not Available
Blood uric acid decreased13.02.04.0040.004638%Not Available
Body temperature increased13.15.01.0010.004638%Not Available
Bone disorder15.02.04.004--Not Available
Breast enlargement21.05.04.001--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Cardiomyopathy02.04.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholecystitis acute09.03.01.0030.004638%Not Available
Chronic hepatitis09.01.07.021; 11.07.01.009--Not Available
Chronic hepatitis B11.05.06.005; 09.01.09.0080.011595%Not Available
Circulatory collapse24.06.02.0010.001210%Not Available
Cleft palate07.05.08.001; 03.04.02.0010.004638%Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
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