Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketorolac tromethamine
Drug ID BADD_D01233
Description Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.[L6358][L6508][L11055][L3674][L11070] It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis.[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511]
Indications and Usage For the short-term (~5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting.
Marketing Status Prescription; Discontinued
ATC Code M01AB15; S01BC05
DrugBank ID DB00465
KEGG ID D00813
MeSH ID D020911
PubChem ID 84003
TTD Drug ID Not Available
NDC Product Code 70518-2927; 0023-2181; 25021-700; 71205-582; 35356-696; 72611-719; 0404-9952; 60687-104; 0409-3796; 60505-1003; 0023-9277; 0338-0076; 71872-7212; 63278-1056; 68083-132; 51662-1488; 35573-450; 50090-2746; 0409-3795; 0404-9884; 50090-4635; 50090-5428; 71205-594; 63323-162; 70518-3308; 45865-613; 71872-7118; 70860-701; 70529-119; 0487-6232; 0404-9883; 50090-4583; 51655-170; 69344-144; 55154-0120; 63323-161; 71872-7234; 72266-119; 68788-8149; 0338-0072; 71872-7132; 61919-138; 66267-418; 63629-2488; 71872-7131; 65862-775; 55150-340; 50090-5013; 70529-121; 70529-120; 80425-0139; 60760-314; 12711-5990; 71872-7213; 62991-2818; 68083-103; 25021-701; 55154-1555; 66993-193; 50090-2762; 68083-134; 76420-250; 72189-335; 71872-7119; 0395-8216; 71872-7022; 43235-0001; 55289-328; 42571-137; 0641-6043; 68071-1787; 55154-9366; 52584-725; 64679-758; 0093-0314; 0641-6041; 55154-9368; 72611-725; 71205-116; 71335-1904; 17478-207; 55154-6960; 69543-388; 71872-7185; 70860-700; 68071-2576; 53069-0620; 14501-0010; 67296-1412; 0641-6042; 76045-107; 0338-0069; 50090-3397; 72189-054; 55154-1556; 68083-104; 72611-722; 68071-2443; 64679-757; 47335-221; 63187-628; 72266-118; 51662-1295; 0409-3793; 55150-341; 50090-3364; 70518-0048; 66267-832; 71872-7188; 51927-0111; 71335-1803; 76045-209; 53002-6990; 63187-128; 51552-1371; 53002-7780; 76420-032; 51927-3443; 76045-104; 70518-2610; 60758-773; 49452-3926; 66577-045; 55154-9398; 63629-2974; 49711-0103; 42291-358; 50090-5609; 0023-3507; 68071-4811; 61314-126; 50090-0601; 55150-339; 66022-0117; 70529-122; 43063-904; 65044-7424; 55111-014; 49452-3919; 76420-252; 71205-296; 68788-7517; 51662-1292; 68071-2400; 47335-219; 47335-220; 38779-2249; 52584-722; 70518-3369; 0378-1134; 66577-016; 68083-133; 68071-2569; 17478-209; 50090-3550; 52584-719; 63187-777; 76045-105; 76420-184; 65862-770; 17478-208; 68071-2252
Synonyms Ketorolac Tromethamine | Acular | Toradol
Chemical Information
Molecular Formula C19H24N2O6
CAS Registry Number 74103-07-4
SMILES C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breast feeding26.05.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.001--
Colitis ulcerative10.02.01.004; 07.08.01.005--Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Corneal deposits06.06.03.002--Not Available
Corneal erosion06.06.03.003--Not Available
Corneal infiltrates06.08.01.002--Not Available
Corneal lesion06.06.03.004--Not Available
Corneal oedema06.04.02.001--Not Available
Corneal perforation12.01.04.003; 06.06.03.006--Not Available
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.015--Not Available
Cystitis20.03.02.002; 11.01.14.001--
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
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